"High complexity" clinical laboratories are approved under the Clinical Laboratory Improvement Amendments to develop, validate, and offer a laboratory-developed test (LDT) for clinical use. The Food and Drug Administration considers LDTs to be medical devices under their regulatory jurisdiction, and that at least certain LDTs should be subject to greater regulatory scrutiny. This review describ...

We present a class of topological plasma configurations characterized by their toroidal and poloidal winding numbers, nt and np, respectively. The special case of nt=1 and np=1 corresponds to the Kamchatnov-Hopf soliton, a magnetic field configuration everywhere tangent to the fibers of a Hopf fibration so that the field lines are circular, linked exactly once, and form the surfaces of nested t...

The first molded gas chromatography (GC) microcolumn is described. This microcolumn consists of a single microtextured thermoset polymer composite which acts as both the structural material and the stationary phase. The resultant microcolumn is inexpensive and has been coupled to a disposable colorimetric sensor array, creating a disposable column-detector unit and demonstrating a proof of conc...

We investigate the windings around the origin of the two-dimensional Markov process (X,L) having the stable Lévy process L and its primitive X as coordinates, in the non-trivial case when |L| is not a subordinator. First, we show that these windings have an almost sure limit velocity, extending McKean’s result [8] in the Brownian case. Second, we evaluate precisely the upper tails of the distri...

We analyze the topological Hall conductivity (THC) of topologically nontrivial spin textures like magnetic vortices and skyrmions and investigate its possible application in the readback for magnetic memory based on those spin textures. Under adiabatic conditions, such spin textures would theoretically yield quantized THC values, which are related to topological invariants such as the winding n...

1. Twelve healthy men drank 0.80 g ethanol kg-1 body weight on four occasions spread over several weeks. Ethanol was given as 96% v/v solvent which was diluted with orange juice to make a cocktail (20-25% v/v). This drink was ingested in exactly 30 min at 08.00 h after an overnight (10 h) fast. 2. Samples of venous blood were obtained at exactly timed intervals of 0, 10, 20, 30, 45, 60, 90, 120...

Although clinical practices evolve over time, the translation of specific research evidence into clinical practice is unpredictable, inconsistent, and complex. In this paper, we use examples from chronic cardiovascular conditions to: 1). highlight two types of care gaps; 2). describe the most common potential barriers to the application of evidence into clinical care; and 3). outline which of t...

A DNA-protein complex modeled by a semiflexible chain and an attractive spherical core is studied in the situation when an external stretching force is acting on one end monomer of the chain while the other end monomer is kept fixed in space. Without a stretching force, the chain is wrapped around the core. By applying an external stretching force, unwrapping of the complex is induced. We study...

A basic problem in gravitational physics is the resolution of spacetime singularities where general relativity breaks down. The simplest such singularities are conical singularities arising from orbifold identifications of flat space, and the most challenging are spacelike singularities inside black holes (and in cosmology). Topology changing processes also require evolution through classically...