A 21‐year‐old male patient presented to department of dermatology with chief complaints of itchy dark‐colored lesion over his left lower leg since 2 months. On examination there was single localized, scaly, hyperpigmented, and eczematous plaque. Diagnosis of nummular eczema was made and patient was advised topical steroid with emollients and oral cetirizine 10 mg per day to control pruritus. Th...

Fixed drug eruption (FDE) usually appears as a solitary/small number of pruritic, well circumscribed, erythematous--violaceous macules that evolve into oedematous plaques which typically resolve after the discontinuation of the offending drug, leaving residual hyperpigmentation. This eruption is considered pathognomonic of a drug-induced dermatosis and is triggered within a few minutes or up to...

BACKGROUND A fixed-drug eruption (FDE) is a reaction characterized by cutaneous lesions that appear due to exposure to a particular drug. Barbiturates, carbamazepine, sulfamethoxazole, and tetracyclines have all been associated with causation of FDEs. Although these drugs are more commonly associated with FDEs, any introduction of a medication has the potential to result in a FDE. Metformin, a ...

Introduction Fixed drug eruption (FDE) is a pattern of a drug-induced skin reaction. It is characterized by skin erythematous plaques that recur at the same site each time the drug is administered. Several drugs have been associated to such cutaneous reaction, including, anticonvulsant agents, sulfonamides, non opioid analgesics and tetracyclines. Non steroidal anti-inflammatory drugs (NSAIDs) ...

Fixed drug eruption (FDE) is a unique type of cutaneous drug reaction that typically recurs in the identical locations on re-exposure to the attributed drug. FDE is characterized by the appearance of a single or multiple sharply demarcated violaceous erythematous plaques which heal with residual hyperpigmentation. A 27-year-old woman presented with multiple dark patches over her eyelids, mouth,...

A fixed drug eruption (FDE) is characterized by the presence of a solitary or multiple, pruritic, well-circumscribed, erythematous plaques. These lesions have tendency to recur at same sites and heal with residual hyperpigmenation. With repeated attacks, the size and/or number of the lesions may increase. So far, more than 100 drugs have been implicated in causing FDEs, including ibuprofen, sul...

Penile lesions are encountered in a variety of fields from family medicine practice through urology, to sexual health specialists. It is important that practitioners consider and recognize fixed drug eruptions of the penis while being able to initiate appropriate treatment in order to avoid misdiagnosis and avoidable stress. In summary, withdrawal of the offending medication and initiation of c...

Successful desensitization protocols have been reported in patients with fi xed drug eruption (FDE) [1-3]. In chronic diseases, it would be desirable to sustain the tolerance achieved after desensitization. Maintained tolerance has been reported in immunoglobulin (Ig) E–mediated hypersensitivity reactions [4,5], but not in FDE. We report the case of a 28-year-old female with cystic fi brosis wh...