background: streptokinase is a bacterial protein produced by different beta hemolytic streptococci and widely used in thrombolytic treatment. the main disadvantage of using streptokinase is antibody formation which causes allergic reaction to neutralize effects of streptokinase therapy. aim of this study was investigate of recombinant mutant streptokinase fibrinolytic activity. m aterials and m...

SYNOPSIS The observation by Todd (1964) of a diffuse fibrinolytic activity related to the human endometrium in its secretory stage initiated a reinvestigation of the development of fibrinolytic activity in the uterus and vagina of the rat using the histochemical fibrin slide technique. In addition to the plasminogen activator known to be related to uterine vessels, in the rat in particular to m...

The observation by Todd (1964) of a diffuse fibrinolytic activity related to the human endometrium in its secretory stage initiated a reinvestigation of the development of fibrinolytic activity in the uterus and vagina of the rat using the histochemical fibrin slide technique. In addition to the plasminogen activator known to be related to uterine vessels, in the rat in particular to myometrial...

Fibrinolytic activity of colic venous and arterial blood has been studied at laparotomy in 18 patients with ulcerative colitis or Crohn's colitis and compared with that of 17 patients with colonic carcinoma or diverticulosis. Using the dilute blood clot lysis time technique, no difference was detected between the fibrinolytic activity in colic venous blood from the two groups. When the clinical...

Natural or spontaneous fibrinolytic activity of the blood is due to a labile activator which is stabilized by fibrin formation. Current methods of measuring spontaneous fibrinolysis require either low temperature centrifugation when plasma is used or photography when diluted whole blood is used and neither is available in the average laboratory. A method of measuring fibrinolytic activity in bl...

Fibrinolytic activity and platelet adhesiveness are normal in cases of angina pectoris and healed myocardial infarction, whereas fibrinolytic activity is diminished in acute myocardial infarction. Exercise increases fibrinolytic activity in normal people but the effect on it of submaximal exercise in patients with ischaemic heart disease is not known. Resting platelet adhesiveness and fibrinoly...

Background Despite the widespread use of fibrinolytic therapy and the numerous reports on its bleeding complications, spontaneous hemarthrosis following fibrinolytic therapy is quite rare. Case Report We describe in this report a patient with no previous history of articular disease who developed a spontaneous right knee bloody effusion following fibrinolytic therapy using rt-PA for acute ST-el...

The urine and serum fibrinolytic activity were measured in dogs following whole body radiation ranging from 450 to 800 r generated by 1,000 kv. and 250 kv. machines. The fibrinolytic activity of the urine showed a precipitate rise 4 to 5 days before death in all dogs with pulmonary hemorrhage as the main cause of death. The fibrinolytic activity of the serum showed a similar rise, which was mos...

Bacillus sp. can biosynthesize fibrinolytic enzymes. Culture conditions and nutrient sources are important factors affecting microbial growth production of the Fibrinolytic enzyme. Therefore, we investigated culture strain ES4, such as temperature, pH, C source (glucose, sucrose, glycerol, maltose), N (yeast extract, meat content, peptone, tryptone), metal ions (Ca 2+ , Mg Mn Zn K + Fe Cu ), ti...