نتایج جستجو برای: fgf8 protein

تعداد نتایج: 1235084  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
James M Clegg Christopher D Conway Kathy M Howe David J Price John O Mason Jeremy E Turnbull M Albert Basson Thomas Pratt

The corpus callosum (CC) connects the left and right cerebral hemispheres in mammals and its development requires intercellular communication at the telencephalic midline mediated by signaling proteins. Heparan sulfate (HS) is a sulfated polysaccharide that decorates cell surface and extracellular matrix proteins and regulates the biological activity of numerous signaling proteins via sugar-pro...

Journal: :Development 2009
Shinichi Miyagawa Anne Moon Ryuma Haraguchi Chie Inoue Masayo Harada Chiaki Nakahara Kentaro Suzuki Daisuke Matsumaru Takehito Kaneko Isao Matsuo Lei Yang Makoto M Taketo Taisen Iguchi Sylvia M Evans Gen Yamada

Embryonic appendicular structures, such as the limb buds and the developing external genitalia, are suitable models with which to analyze the reciprocal interactions of growth factors in the regulation of outgrowth. Although several studies have evaluated the individual functions of different growth factors in appendicular growth, the coordinated function and integration of input from multiple ...

Journal: :Mechanisms of Development 2000
Tatsuya Katahira Tatsuya Sato Sayaka Sugiyama Tatsuya Okafuji Isato Araki Jun-ichi Funahashi Harukazu Nakamura

Otx2 is expressed in the mesencephalon and prosencephalon, and Gbx2 is expressed in the rhombencephalon around stage 10. Loss-of-function studies of these genes in mice have revealed that Otx2 is indispensable for the development of the anterior brain segment, and that Gbx2 is required for the development of the isthmus. We carried out gain-of-function experiments of these genes in chick embryo...

Journal: :Development 2007
Chao Guo Hai-Yan Qiu Ying Huang Haixu Chen Rong-Qiang Yang Sheng-Di Chen Randy L Johnson Zhou-Feng Chen Yu-Qiang Ding

Secreted factors FGF8 and WNT1 are essential either for the inductive activity of the isthmus organizer or for the regionalization of the midbrain-hindbrain boundary (MHB). However, transcriptional regulation of these secreted factors during development remains to be elucidated. Here we show that the LIM homeobox gene Lmx1b is expressed in the anterior embryo as early as E7.5 and its expression...

Journal: :Developmental biology 2004
Christopher B Brown Jennifer M Wenning Min Min Lu Douglas J Epstein Erik N Meyers Jonathan A Epstein

Tbx1 has been implicated as a candidate gene responsible for defective pharyngeal arch remodeling in DiGeorge/Velocardiofacial syndrome. Tbx1(+/-) mice mimic aspects of the DiGeorge phenotype with variable penetrance, and null mice display severe pharyngeal hypoplasia. Here, we identify enhancer elements in the Tbx1 gene that are conserved through evolution and mediate tissue-specific expressio...

Journal: :Current Biology 2009
Xianling Zhao Ioan Ovidiu Sirbu Felix A. Mic Natalia Molotkova Andrei Molotkov Sandeep Kumar Gregg Duester

Retinoic acid (RA) is thought to be a key signaling molecule involved in limb bud patterning along the proximodistal or anteroposterior axes functioning through induction of Meis2 and Shh, respectively. Here, we utilize Raldh2-/- and Raldh3-/- mouse embryos lacking RA synthesis to demonstrate that RA signaling is not required for limb expression of Shh and Meis2. We demonstrate that RA action i...

2018
Junwon Lee Sang-Hwi Choi Dongjin R Lee Dae-Sung Kim Dong-Wook Kim

The objective of this study was to induce the production of isthmic organizer (IsO)-like cells capable of secreting fibroblast growth factor (FGF) 8 and WNT1 from human embryonic stem cells (ESCs). The precise modulation of canonical Wnt signaling was achieved in the presence of the small molecule CHIR99021 (0.6 μM) during the neural induction of human ESCs, resulting in the differentiation of ...

2015
Weijie Wu Shuping Gu Cheng Sun Wei He Xiaohua Xie Xihai Li Wenduo Ye Chunlin Qin Yiping Chen Jing Xiao Chao Liu Xin Zhang

In palatogenesis, palatal shelves are patterned along the mediolateral axis as well as the anteroposterior axis before the onset of palatal fusion. Fgf10 specifically expressed in lateral mesenchyme of palate maintains Shh transcription in lateral epithelium, while Fgf7 activated in medial mesenchyme by Dlx5, suppressed the expansion of Shh expression to medial epithelium. How FGF signaling pat...

Journal: :Development 2001
T Sato I Araki H Nakamura

The mes/metencephalic boundary (isthmus) has an organizing activity for mesencephalon and metencephalon. The candidate signaling molecule is Fgf8 whose mRNA is localized in the region where the cerebellum differentiates. Responding to this signal, the cerebellum differentiates in the metencephalon and the tectum differentiates in the mesencephalon. Based on the assumption that strong Fgf8 signa...

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