The surface-localized M protein of Streptococcus pyogenes is a major virulence factor that inhibits phagocytosis, as determined ex vivo. Because little is known about the role of M protein in vivo we analyzed the contribution of different M protein regions to virulence, using the fibrinogen (Fg)-binding M5 protein and a mouse model of acute invasive infection. This model was suitable, because M...

Background: The purpose of this study was to review key differences between necrotizing soft tissue infections (NSTI) and Fournier’s Gangrene (FG) in demographics, comorbidities, laboratory findings, cost, and clinical course. Methods: The burn registry of a Level 1 trauma and burn center in Lubbock, Texas was used to identify and retrospectively review medical records of patients with NSTIs an...

Identifying the neural underpinnings of socio-emotional deficits in 22q11.2 deletion syndrome (22q11DS) may elucidate recurrent psychosis in affected individuals. In the current study, we investigate volumetric changes in 22q11DS to the fusiform gyrus (FG), a region associated with hypoactivity during fMRI, by manually tracing the FG in 42 individuals with 22q11DS and 54 healthy controls. Large...

The 3-Colouring of a graph is a classic NP-complete problem. We show that some solutions for the 3-Colouring can be built in polynomial time based on the number of basic cycles existing in the graph. For this, we design a reduction from proper 3-Colouring of a graph G to a 2-CF Boolean formula FG, where the number of clauses in FG depends on the number of basic cycles in G. Any model of FG prov...

Nuclear pore proteins with phenylalanine-glycine repeats are vital to the functional transport of molecules across the nuclear pore complex. The current study investigates the binding of these FG-nucleoporins to the Cse1p:Kap60p:RanGTP nuclear export complex. Fourteen binding spots for FG-nucleoporin peptides are revealed on the surface of Cse1p, and 5 are revealed on the Kap60p surface. Taken ...

The ability to recognize a shape is linked to figure-ground (FG) organization. Cell preferences appear to be correlated across contrast-polarity reversals and mirror reversals of polygon displays, but not so much across FG reversals. Here we present a network structure which explains both shape-coding by simulated IT cells and suppression of responses to FG reversed stimuli. In our model FG seg...

Abstract: This paper presents scaling of Floating-Gate (FG) devices, and the resulting implication to large-scale Field Programmable Analog Arrays (FPAA) systems. The properties of FG circuits and systems in one technology (e.g., 350 nm CMOS) are experimentally shown to roughly translate to FG circuits in scaled down processes in a way predictable through MOSFET physics concepts. Scaling FG dev...

PURPOSE To assess the point prevalence of undetected prediabetes (preDM) and diabetes mellitus (DM) in patients treated with antipsychotics and to compare metabolic parameters between patients with normoglycemia (NG), preDM, and DM. Furthermore, conversion rates for preDM and DM were determined in a 1-year follow-up. PATIENTS AND METHODS In a naturalistic cohort of 169 patients, fasting gluco...

Gastric adenocarcinoma of the fundic gland (chief cell-predominant type, GA-FG-CCP) is a rare variant of well-differentiated adenocarcinoma, and has been proposed to be a novel disease entity. GA-FG-CCP originates from the gastric mucosa of the fundic gland region without chronic gastritis or intestinal metaplasia. The majority of GA-FG-CCPs exhibit either a submucosal tumor-like superficial el...