The medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) coordinate various stress responses. Although the effects of stressors on mPFC and BLA activity have been previously examined, it remains unclear to what extent stressors affect functional interactions between these regions. In vivo electrophysiology in the anesthetized rat was used to examine mPFC and BLA activity simultaneousl...

A growing awareness of the risks associated with extensive intestinal metabolism has triggered an interest in developing robust methods for its quantitative assessment. This study explored the utility of intestinal S9 fractions, human liver microsomes, and recombinant cytochromes P450 to quantify CYP3A-mediated intestinal extraction in humans for a selection of marketed drugs that are predomina...

Inherited fibrinogen (FG) disorders are rare and result in quantitative or/and qualitative FG deficiency. While the majority of patients with clinically relevant FG deficiencies demonstrate a bleeding phenotype, a subset of patients are at increased risk of thrombosis. Patients and methods: We report a 54-years old man presenting with a thrombophilic phenotype characterized by two episodes of u...

Retinal ganglion cells (RGCs) in rats were retrogradely labeled with the fluorescent tracer Fluorogold (FG) and subjected to GAP-43 and c-JUN immunocytochemistry to identify those RGCs that are capable of regenerating an axon. After optic nerve section (ONS) and simultaneous application of FG to the nerve stump (group 1 experiments), GAP-43 immunoreactive RGCs (between 2 and 21 days after ONS) ...

Cattle are noted carriers of the foodborne pathogen Salmonella enterica. The perceived need to decrease the potential human health risk posed by excretion of this pathogen has resulted in numerous studies examining the factors that influence Salmonella shedding in cattle. Fecal grab (FG) samples have been the predominant method used to identify cattle colonized or infected with Salmonella; howe...

BACKGROUND/AIM Anastomotic leakage remains a frequent and serious complication in gastrointestinal surgery. In order to reduce its incidence, several clinical and experimental studies on anastomotic sealing have been performed. In a number of these studies, the sealing material has been fibrin glue (FG), and the results in individual studies have been varying. The positive effect of anastomotic...

The localization of three known alpha-granule proteins, thrombospondin (TSP), von Willebrand factor (vWF), and fibrinogen (Fg) has been studied in human megakaryocytes (MK) by immunofluorescence and immunoelectron microscopy. For this study, highly purified populations of MK were prepared from human bone marrow either by counterflow centrifugal elutriation or by cell culture from normal subject...

Die Beiträge wurden wie immer sehr intensiv und auch konträr diskutiert. Die Diskussionen wurden in den Pausen und beim gemeinsamen Abendessen in einer netten Ulmer Gaststätte fortgeführt. Kurze Zusammenfassungen der Beiträge finden Sie im Anschluss an diesen Bericht; die Folien zu den Vorträgen sind auf der web-Seite der Fachgruppe verfügbar. Auch in diesem Jahr berichtete der Arbeitskreis "RE...

Den Abschluss des Treffens bildeten die Be-richte aus den Arbeitskreisen der Fachgruppe. Klaus Schmid vom ISES Kaiserslautern fasste die erzielten Ergebnisse des AK "RE für Produktlinien" zusammen. Frank Houdek berichtete, dass der AK "RE-Prozesse" seine Arbeiten abgeschlossen hat und präsentierte die erzielten Ergebnisse. Eine Pub-likation der Ergebnisse wird angestrebt. Abschlie-ßend stellte ...

Am 17. und 18. November 2005 fand im Novotel München-Neuperlach das 23. Treffen der Fachgruppe Test, Analyse und Verifikation von Software (TAV) statt. Den über 40 Teilnehmenden aus Industrie, öffentlicher Verwaltung und Hochschulen wird das Treffen aufgrund seines stimulierenden Workshop-Charakters und nicht zuletzt auch aufgrund des überaus freundlichen Ambientes und des hervorragend umsorgte...