BACKGROUND The objective was to determine the incidence and volume of fetomaternal hemorrhage (FMH) in normal vaginal delivery and in delivery by cesarean section. Determination of these variables would enable optimalization of guidelines for D alloimmunization prophylaxis. STUDY DESIGN AND METHODS In a prospective cohort study, a total of 3457 examinations were performed, 2413 after normal v...

BACKGROUND Evidence for an association between exposure during pregnancy to trihalomethanes (THMs) in drinking water and impaired fetal growth is still inconsistent and inconclusive, in particular, for various exposure routes. We examined the relationship of individual exposures to THMs in drinking water on low birth weight (LBW), small for gestational age (SGA), and birth weight (BW) in single...

The initiation of cells in fetal skin was studied by exposing pregnant Ha/ICR mice intragastrically to single doses of a carcinogen at different times during gestation. For comparison, adult mice were exposed to the same carcinogen in a similar manner. The carcinogen, 7,12-dimethylbenz(a)anthracene (DMBA), was given at a dose of about 120 mg/kg in 0.2 ml sesame oil by gavage to 7-week-old pregn...

Effects of Sodium Selenite on Methylmercury Embryotoxicity and Teratogenicity in Mice. NOBUl'AGA, T., SATOH, H., AND SUZUKI, T. (1979). Toxicol. Appl. Pharmacal. 47, 79-88. Female IVCS mice were fed food containing methylmercury (MeHg) at 0, 15.9, or 31.9 nmol g food and drinking water containing sodium selenite at 0, 11.4, or 22.8 nmol·ml for 30 days before gestation and thereafter up to Day 1...

This study aims to determine the ability of Modified Foam Stability (FS-50) test predict fetal lung maturity in preterm premature rupture membranes treated with Dexamethasone. The sample included pregnant women PROM at a gestational age 24 less than 34 weeks ER and Obstetrics Ward Sanglah Central General Hospital, Denpasar. patient underwent vaginal speculum examination collect fluid pooled vag...

Phthalate chemical plasticizers can damage the fetal and postnatal mammalian testis, but several aspects of the injury mechanism remain unknown. Using a genome-wide microarray, the profile of testicular gene expression changes was examined following exposure of postnatal day 28 rats to a single, high dose (1000 mg/kg) of mono-(2-ethylhexyl) phthalate (MEHP). By microarray analysis, approximatel...

Ionising radiation is a known leukaemogen and in utero exposure to diagnostic X-rays associates with increased risk of childhood leukaemia (see abstract by R. Wakeford). This paper examines the methodology used by the International Commission on Radiological Protection (ICRP) to estimate doses to the child following in utero radionuclide exposures, considers experimental evidence for in utero h...

The transplacental transfer of cefuroxime was determined at antenatal fetal blood sampling in a cross sectional study of 78 patients between 15-35 weeks' gestation, 8-138 minutes after a maternal intravenous dose of 750 mg. Mean serum cefuroxime concentration, measured by high performance liquid chromatography, was 7.4 (95% confidence interval (CI) 6.8 to 8.1) mg/l in control fetuses; concentra...

This article proposes tree-structured logistic regression modeling for over-dispersed binomial data. Recursive partitioning is performed using a combination of statistical tests and residual analysis. The splitting criterion in cross-validation is based on the deviance function. A nested grid algorithm to estimate the bootstrap parameters is developed. The regression tree procedure provides a n...