3,5,5-Trimethylhexanoyl (TMH)-ferrocene has been used to produce iron loading in whole animals and in cultured hepatocytes. Iron loading produced by TMH-ferrocene is highly efficient and, of the compounds used to produce iron loading in experimental systems, most closely mimics the loading patterns observed in the human disease hemochromatosis. Previous work with TMH-ferrocene has shown that TM...

A catalytic system consisting of the ruthenium(II) complex [Ru(η³-2-C3H4Me)(CO)(dppf)][SbF6] (dppf=1,1'-bis(diphenylphosphino)ferrocene) and trifluoroacetic acid has been used to promote the coupling of secondary propargylic alcohols with 6-chloro-4-hydroxychromen-2-one. The reactions afforded unusual 2-methylene-2,3-dihydrofuro[3,2-c]chromen-2-ones in good yields.

BT-SeCF 2 H is introduced as a nucleophilic reagent for the deoxygenative difluoromethylselenylation of readily available carboxylic acid and alcohols.

An NAD-dependent D-lactate dehydrogenase (D-nLDH) of Lactobacillus bulgaricus ATCC 11842 was rationally re-designed for asymmetric reduction of a homologous series of α-keto carboxylic acids such as phenylpyruvic acid (PPA), α-ketobutyric acid, α-ketovaleric acid, β-hydroxypyruvate. Compared with wild-type D-nLDH, the Y52L mutant D-nLDH showed elevated activities toward unnatural substrates esp...

Here we present a series of linked cage complexes of functionalised variants of the octametallic ring {Cr7Ni} with the general formula [(n)Pr2NH2][Cr7NiF8(O2C(t)Bu)15(O2CR)], where HO2CR is a N-heterocycle containing carboxylic acid. These compounds are made by reacting [(n)Pr2NH2][Cr7NiF8(O2C(t)Bu)15(O2CR)] with a variety of simple metal salts and metal dimers. The carboxylic acids studied inc...

The pterins xanthopterin (2-amino-4:6-dihydroxypteridine) (Koschara, 1936) and biopterin (2amino 4 hydroxy-6-[1: 2-dihydroxypropyl (L-erythro)]-pteridine) (Patterson, Saltza & Stokstad, 1956) have been isolated from human urine. It has been suggested that the pterins 2-amino-4-hydroxypteridine-6-carboxylic acid, 2-amino-4-hydroxypteridine and isoxanthopterin (2-amino-4:7-dihydroxypteridine) are...