BackgroundTo characterize the prevalence and profile of drug–drug interactions (DDIs), drugs most related to major DDIs risk factors their prescription in a neonatal intensive care unit (NICU).MethodsNeonates admitted NICU who had at least one medication prescribed hospital stay >24 h were included prospective cohort study (August 2017 July 2018). All medications during hospitalization collecte...

background: although some patients can tolerate colonoscopy procedure using fentanyl/ midazolam without any sedation and analgesic requirements but some patients may require additional sedation with benzodiazepines. we performed the present study to compare the effect of paracetamol/midazolam with fentanyl/ midazolam. methods: in a clinical trial, 96 patients aged 18 to 75 years old, who were c...

Introduction: Breakthrough Pain (BTP) is experienced as mild to moderate-severe pain, from only a few seconds hours. It causes decrease in the quality of life and functional capacities. Furthermore, BPT must be recognizable, assessed, controlled prevent its relapse severity. Case report: A woman, 45 years old, having breast cancer along with pulmonary, femur, cervical metastases, came main comp...

Previous studies have shown that uptake of the lipophilic opioid, fentanyl, by pulmonary endothelial cells occurs by both passive diffusion and carrier-mediated processes. To evaluate if the latter mechanism also exists in brain endothelium, transport of [H]fentanyl was examined in primary cultured bovine brain microvessel endothelial cell (BBMEC) monolayers. Uptake of fentanyl appears to occur...

The predictors of postoperative pain and analgesic consumption were previously found to include preoperative pain, anxiety, age, type of surgery, and genotype, but remaining unclear was whether intraoperative factors could predict postoperative pain. In the present study, we investigated the time-course of fentanyl consumption using intravenous patient-controlled analgesia records from patients...

BACKGROUND Opioids can be a safe and effective option for carefully selected patients with a structured treatment program that includes consistent monitoring. However, the benefits and risks of opioid therapy for patients with chronic pain, and society as a whole, have been sharply debated. A key component of this debate has involved the administration of rapid-onset opioids for the management ...

BACKGROUND Our aim was to assess the efficacy of thoracic epidural anesthesia (EA) followed by postoperative epidural infusion (EI) and patient-controlled epidural analgesia (PCEA) with ropivacaine/fentanyl in off-pump coronary artery bypass grafting (OPCAB). METHODS In a prospective study, 93 patients were scheduled for OPCAB under propofol/fentanyl anesthesia and randomized to three postope...

Background: The addition of fentanyl to spinal ropivacaine anaesthesia has been shown to improve the quality of block, increase duration of sensory block, and provide postoperative analgesia without affecting motor function. In a randomized controlled, double blind study, we examined the efficacy and the adverse effects of three different regimen of spinal anesthesia. Methods: Forty-five patien...

background: we administered paracetamol and fentanyl at the beginning of phacoemulsification cataract surgery. we think that paracetamol administered alone is as effective as fentanyl in treating pain after cataract surgery with fewer side effects during operation and in post anesthesia care unit (pacu). the goal of this study was to compare to the postoperative pain relief effect of paracetamo...