NR5A1 is essential for the development and for the function of steroid producing glands of the reproductive system. Moreover, its misregulation is associated with endometriosis, which is the first cause of infertility in women. Hr39, the Drosophila ortholog of NR5A1, is expressed and required in the secretory cells of the spermatheca, the female exocrine gland that ensures fertility by secretin...

Endocrine complications due to haemosiderosis are present in a significant number of patients with beta-thalassemia major (BTM) worldwide and often become barriers in their desire for parenthood. Thus, although spontaneous fertility can occur, the majority of females with BTM is infertile due to hypogonadotropic hypogonadism (HH) and need assisted reproductive techniques. Infertility in these w...

1.1 Regulation of female reproductive system Regulation of female reproductive system consists of very complex interactions between the hypothalamus, neurohypophysis and ovaries. Beginning from the embryologic stage, female reproductive system is regulated by the brain. Ovarian hormone production is supressed by the hypothalamo-hypophyseal control mechanism till the end of the childhood period ...

The Damaraland mole-rat is a subterranean mammal exhibiting extreme reproductive skew with a single reproductive female in each colony responsible for procreation. Non-reproductive female colony members are physiologically suppressed while in the colony, exhibiting reduced concentrations of plasma luteinizing hormone (LH) and a decreased response of the pituitary, as measured by the release of ...

T h e control o f female fertility by al imentary tract vaccination with sperm antigens has remained a theoretical possibility connect ing observations of sperm immunogenici ty and consequent infertility in various species, including humans (for review see references 1-3), with the translation o f gut mucosal immune reactivity to anatomically r emote mucosal sites, including the female genital ...