Considering the proposed preventive effect of nervonic acid on obesity- and diabetes-related coronary risk factors, the content of its precursors (oleic, 11-eicosenoic and 13-docosenoic acids) was measured in liver and plasma phospholipids and triglycerides, brain and spleen phospholipids, and adipose tissue lipids of fed or overnight fasted control and hereditarily diabetic Goto-Kakizaki femal...

Female rats show a distinct attraction for males. This attraction remains consistent without the necessity for the physical presence of the male. However, the identity of the olfactory cues contributing to attraction in rats remains unknown. Rat urine contains copious amounts of major urinary proteins (MUPs). Here, we investigated the hypothesis that MUPs mediate sexual attractiveness in rats. ...

SUMMAEY The effect of cortisone (total dose--~4 rag/rat and 12 mg/mouse) on the distribution of fluorene-2,7-di(sulfonamido-2-naphthalene)-S 35 6 hours following intravenous injection of this compound into Wistar rats and CAF~/Jax mice was studied. Both sexes and species treated with cortisone showed significant reduction in the weights of thymus and spleen, except that there was no effect on t...

SUMMAEY The effect of cortisone (total dose--~4 rag/rat and 12 mg/mouse) on the distribution of fluorene-2,7-di(sulfonamido-2-naphthalene)-S 35 6 hours following intravenous injection of this compound into Wistar rats and CAF~/Jax mice was studied. Both sexes and species treated with cortisone showed significant reduction in the weights of thymus and spleen, except that there was no effect on t...

Heavy body weight (BW) is thought to be associated with reduced longevity and age-associated diseases, including cancer, both in laboratory rodents and humans. To further investigate the interactions between BW, longevity and spontaneous tumor development, we measured the correlations between BW in early life, BW in middle life, and parameters of life span and tumorigenesis in male and female o...

The present study was conducted to ascertain the estrogenic effect of Zhuang Medicated Thread Moxibustion (ZMTM) and explore its time-sensitive impact on estradiol (E2) in female perimenopausal rats. 40 rats were randomized into four groups: control, model, ZMTM, acupuncture groups. syndrome induced last three groups with a daily subcutaneous dose 80 mg/kg 4-vinylcyclohexene diepoxide for 15 da...

background: affecting the female reproductive organ and the layers around the oocyst, some ration ions could facilitate the penetration of sperm with specific chromosome type and change the sex ratio in mammal infants. objectives: the purpose of the present study was to evaluate the effect of potassium supplement on the sex ratio in rat. methods: the percentage of moisture, ash, crude fat and p...

We report here the toxic effects of chlorpyrifos, a broad-spectrum organophosphorous insecticide, on female reproductive function in rat model. We observed significant alterations in the rhythmicity and phasic cellular characteristics of estrous cycle with a concomitant increase in diestrus index in chlorpyrifos treated female rats in a dosedependent manner (5.4 and 8.1 mg/Kg.b.wt./day) compare...

Recently, it was shown that the orexigenic effect of melanin-concentrating hormone (MCH) is attenuated by estradiol treatment in ovariectomized (OVX) rats. This suggests that female rats may be less responsive than male rats to the behavioral effects of MCH. To investigate this hypothesis, the effects of lateral ventricular infusions of MCH on food intake, water intake, meal patterns, and runni...

Rapamycin slows disease progression in the male Han:SPRD (Cy/+) rat with polycystic kidney disease (PKD). The aim of this study was to determine the effect of rapamycin on PKD and the relative contributions of the proproliferative mammalian target of rapamycin complexes 1 and 2 (mTORC1 and mTORC2) in female Cy/+ rats. Female Cy/+ rats were treated with rapamycin from 4 to 12 wk of age. In vehic...