نتایج جستجو برای: felodipine

تعداد نتایج: 381  

2015
Jörg Striessnig Nadine J. Ortner Alexandra Pinggera

Inhibition of voltage-gated L-type calcium channels by organic calcium channel blockers is a well-established pharmacodynamic concept for the treatment of hypertension and cardiac ischemia. Since decades these antihypertensives (such as the dihydropyridines amlodipine, felodipine or nifedipine) belong to the most widely prescribed drugs world-wide. Their tolerability is excellent because at the...

Journal: :Biomedical chromatography : BMC 2007
Jing Jing Weichao Ren Xijing Chen Hui He Wei Zhou Xuping Zhu Ya Sun Guangji Wang

A sensitive HPLC/ESIMS method was established for the determination of manidipine in human plasma and pharmacokinetics study. After basified plasma with ammonia, manidipine and the internal standard (IS) (felodipine) were extracted with n-hexane and separated on a Hypersil ODS2 column with a mobile phase of methanol-5 mm ammonium acetate solution containing 0.1% acetic acid (85:15, v/v). MS det...

2012
Gaurav Kumar Sharma Pramod Kumar Sharma Mayank Bansal

Department of Pharmaceutical Technology, Meerut Institute of Engineering & Technology, NH-58, Baghpat Road-Bypass Crossing, Meerut-250005 (U.P), India ABSTRACT Drug release from mucoadhesive patches at predetermined rate in oral cavity having distinct advantages over traditional dosage forms as tablets, gels and solutions. This review provides brief information about method of preparation and e...

2014
Khalid Akhter Ansari Kunal Pratap Pagar Shoeb Anwar Pradeep Ratilal Vavia

The objective of this research work was to design, develop and optimize the self micro-emulsifying drug delivery system (SMEDDS) of Felodipine (FL) filled in hard gelatine capsule coated with polymer in order to achieve rapid drug release after a desired time lag in the management of hypertension. Microemulsion is composed of a FL, Lauroglycol FCC, Transcutol P and Cremophor EL. The optimum sur...

Journal: :Asian Journal of Pharmaceutical and Clinical Research 2021

Objective: Felodipine (FD) is an effective Biopharmaceutics Classification System Class II calcium channel blocker mainly used in the management of hypertension and angina pectoris. It has poor solubility low oral bioavailability (15%). To overcome these disadvantages to maintain constant plasma concentration for maximum therapeutic activity, there a need design alternative route, that is, tran...

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