Basophilic hepatic foci, nodules, and trabecular hepatocellular carcinomas, collectively referred to as focal hepatic lesions, were induced by single injections of 5.0 micrograms of diethylnitrosamine (DEN) per gram body weight in 15-day-old C57BL/6J X C3HeB/FeJ F1 (B6C3 F1) mice. Groups of eight experimental and eight control mice were killed at 3 days and at 1, 2, 4, 10, 20, 28, 36 and 41 wee...

Kinetics of hepatocarcinogenesis was evaluated in 15-day-old male C57BL/6J X C3HeB/FeJ F1 mice using a nontoxic carcinogenic dose range of diethylnitrosamine (DEN). The carcinogen was injected i.p. once, and the animals were killed according to the protocol. Two studies were carried out sequentially over a period of 4 years. In the first study, groups of mice were treated with 0.625, 1.25, 2.5,...

With an emphasis on assessment of reproducibility and precision of results, the technique of Mossbauer spectroscopy is applied to three groups of materials with increasing structural complexity: simple mineral standards, multivalent and multisite ferruginous micas, and multisite silicate glasses. In order to study the underlying accuracy of Mossbauer measurements of minerals, two mineral standa...

The uses of experimental chimeras to transmit lethal genes are discussed. A s an example, the X-linked lethal mutation jp was genetically transmitted by a chimeric male. This male produced abnormal offspring when bred t o j p l + and m s d l f females. Thus, allelism of the mutations jp and msd is proven and the symbol for msd should be changed tojpmsd Of the many known X-linked genes in the mo...

A new sort of generative grammar (Sec2) will be demonstrated which is more radically “lexicalist” than any earlier one (Sec1). It is a modified Unification Categorial Grammar [1–4] from which even the principal syntactic “weapon” of CGs, Function Application, has been omitted. What has remained is lexical sign and the mere technique of unification as the engine of combining signs. The computati...

22 Mice that carry a mutation in a calcium binding domain of Otoferlin, the putative calcium sensor at hair cell 23 synapses, have normal distortion product otoacoustic emissions (DPOAEs) but auditory brain stem responses 24 (ABRs) are absent. In mutant mice mechanotransduction is normal but transmission of acoustic information to 25 the auditory pathway is blocked even before the onset of hear...