There has never been a time when evidence was more important or under such intense scrutiny. A every key study is eagerly awaited and devoured on arrival as though the health hopes of global community rest its shoulders. And yet, we know, frequently flawed, equivocal in findings open to interpretation, even it forms critical element most guidelines decision support tools. Over recent years conc...

Buxton, Orfeu M., Mireille L’Hermite-Balériaux, Fred W. Turek, and Eve Van Cauter. Daytime naps in darkness phase shift the human circadian rhythms of melatonin and thyrotropin secretion. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278: R373–R382, 2000.—To systematically determine the effects of daytime exposure to sleep in darkness on human circadian phase, four groups of subjects pa...

Motivated by a desire to reduce the morbidity of a well-established and effective procedure for coronary artery disease, up to 25% of coronary artery bypass operations are being performed without the use of a heart-lung pump. Concerns remain about the quality of the coronary anastomoses and the completeness of revascularization. Randomized trials have not revealed the significant reduction in m...

The outbreak of enterohaemorrhagic Escherichia coli in Germany last year and recent reports about the emergence of Salmonella Kentucky as a “new superbug” have re-focused public attention on food-borne diseases. Salmonellosis is an important cause of food-borne disease with significant economic burden to the population and healthcare systems. In the last century, microbiologists have identified...

Donahue, Henry J., Zhongyong Li, Zhiyi Zhou, and Clare E. Yellowley. Differentiation of human fetal osteoblastic cells and gap junctional intercellular communication. Am. J. Physiol. Cell Physiol. 278: C315–C322, 2000.—Gap junctional channels facilitate intercellular communication and in doing so may contribute to cellular differentiation. To test this hypothesis, we examined gap junction expre...

Zhu, Peili, Li Lu, Ya Xu, Clifford Greyson, and Gregory G. Schwartz. Glucose-insulin-potassium preserves systolic and diastolic function in ischemia and reperfusion in pigs. Am. J. Physiol. Heart Circ. Physiol. 278: H595–H603, 2000.—Clinical and experimental studies have suggested benefit of treatment with intravenous glucose-insulin-potassium (GIK) in acute myocardial infarction. However, pati...

Cadorette, C., B. Sicotte, M. Brochu, and J. St-Louis. Effects of potassium channel modulators on myotropic responses of aortic rings of pregnant rats. Am. J. Physiol. Heart Circ. Physiol. 278: H567–H576, 2000.—The contribution of potassium channels [ATP-sensitive potassium (KATP) and high-conductance calcium-activated potassium (BKCa) channels] in the resistance of aortic rings of term pregnan...