OBJECTIVE The objective of this study was to determine the yield of diagnostic workup in children presenting with complex febrile seizures. METHODS We performed a retrospective review of charts of patients who presented to our pediatric emergency department with complex febrile seizures (focal, prolonged, or recurrent). Patients with known seizure disorder, congenital central nervous system m...

Interaction between immune-inflammatory process and genetic factors might be implicated in the pathogenesis of febrile seizures. Pre-microRNA (miR)-146a rs2910164 polymorphism is postulated to modulate expression of miR-146a whose anti-inflammatory role involves regulation of high-mobility group box 1. Our aim is to examine whether rs2910164 polymorphism influences serum high-mobility group box...

BACKGROUND Febrile seizures are common in young children. Annual peaks in incidence mirror increased respiratory virus activity during winter. Limited virological data are available using modern diagnostic techniques for children with febrile seizures. We aimed to determine the frequency of detection of specific viral pathogens in children with febrile seizures, to describe risk factors includi...

Commentary Multiple steps and prerequisites may cause delay and variability in the recognition and treatment of febrile seizures and febrile status epilepticus. Among the challenges are identification of patients at risk of febrile convulsive status and detection of febrile seizures and febrile status epilep-ticus. If symptoms are noted by nonmedical personnel, including parents or caretakers, ...

Although most febrile seizures do no harm and two-thirds of initial cases have no witnessed recurrence, the seizures cause much family anxiety, and are sometimes prolonged. In rare cases they are the first evidence of important epilepsy syndromes or are implicated in the development of epilepsy with mesial temporal sclerosis in later life. There have been trials of prophylactic treatment with a...

Febrile seizures are the commonest acute neurological disorder of early childhood. Studies suggested that febrile seizures are previous acute events from a more serious neurological problem. Due to neuron-specific enolase is generally accepted as a marker for neuropathological processes in the brain, 16 pediatric patients were studied during their first seizures and a year after it. Neuron-spec...

Febrile seizures occurring in the neonatal period, especially when prolonged, are thought to be involved in the later development of mesial temporal lobe epilepsy (mTLE) in children. The presence of an often undetected, underlying cortical malformation has also been reported to be implicated in the epileptogenesis process following febrile seizures. This paper highlights some of the various ani...

OBJECTIVE The relationship between iron status and febrile seizures has been examined in various settings, mainly in the Developing World, with conflicting results. The aim of this study was to investigate any association between iron deficiency and febrile seizures (FS) in European children aged 6-60 months. DESIGN Prospective, case-control study. SETTING Greek population in Thessaloniki. ...

BACKGROUND Febrile seizures are commonly encountered in emergency paediatric practice. Initial pre-hospital intervention given by caregivers has been shown to impact outcome. OBJECTIVES To describe the spectrum of pre-hospital interventions given for the treatment of childhood febrile seizures in Ibadan, Nigeria. METHODS All consecutive cases of febrile seizures seen at the emergency room o...

Background: Febrile seizures are the most common convulsive disorder in children. There is growing evidence that vitamin D can affect gene expression and modulate various cell metabolisms. Also vitamin D may have a role in the etiology of febrile seizures. We aimed to explore vitamin D status in children with febrile seizure. Materials and Methods: This cross-sectional study was conducted on 40...