Chemotherapy induced febrile neutropenia predisposes patients to life threatening infections. We aimed to determine the causative microorganisms, infection focus and antibiotic treatment success in febrile neutropenic children with leukemia. A total of 136 febrile neutropenic episodes in 48 leukemic children were reviewed retrospectively from records. Among 136 febrile neutropenic episodes, 68 ...

lthough the diagnosis and treatment of febrile neutropeia episodes have improved significantly over the past two ecades, sepsis is still a major cause of mortality and morbidty in patients undergoing chemotherapy regimens that cause ntensive myelosuppression.1–4 Even in institutions where arly initiation of antibiotic therapy and advances in suportive measures have significantly reduced the mor...

INTRODUCTION Febrile neutropenia (FN) is a significant cause of mortality and morbidity in oncology and haematology units worldwide. The overall mortality in hospital surveys in Singapore surveys on post-chemotherapy FN has ranged between 3.0% and 8.8%. However, recent evidence indicates that outpatient management of patients with low-risk FN is safe and cost-effective. MATERIALS AND METHODS ...

BACKGROUND Febrile neutropenia is a common complication of therapy in children with cancer. Some patients are at low risk of complications, and research has considered reduction in therapy for these patients. A previous systematic review broadly considered whether outpatient treatment and oral antibiotics were safe in this context and concluded that this was likely to be the case. Since that re...

AIM OF THE STUDY PROFIL was a prospective observational study conducted to investigate physicians' evaluation of febrile neutropenia (FN) risk and reasons for giving pegfilgrastim primary prophylaxis (PP) in routine clinical practice in Poland. MATERIAL AND METHODS Adult cancer patients treated with chemotherapy (CT), assessed by investigators as having high overall FN risk, and who received ...

STUDY OBJECTIVE To determine treatment outcomes and economic impact of a ciprofloxacin stepdown program for high-risk febrile neutropenic adults from the hospital's perspective. DESIGN Unblinded, two-phase, single-center study. SETTING Adult leukemia and stem cell transplant unit. PATIENTS High-risk adults with febrile neutropenia. INTERVENTION Two conditions were analyzed: a multidisci...

We conducted a prospective cohort study in a single tertiary hospital with the aim of assessing predictors of multidrug-resistant bacteremia in 307 cases of febrile neutropenia in adult patients with cancer. On multivariate analysis using stepwise logistic regression, age (P = .009), duration of neutropenia (P = .022), and presence of an indwelling central venous catheter (P = .022) were associ...

Neutropenia is a common complication of bone marrow dysfunction following chemotherapy in haematology inpatients [1,2]. Many factors put these patients at increased risk of life threatening infection including compromised mucosal barriers secondary to chemotherapy or radiotherapy and multiple intravenous access devises, in addition to neutropenia. In such patients fever may be the only indicato...