Non-alcoholic fatty liver disease (NAFLD) covers a spectrum of disorders ranging from simple steatosis (non-alcoholic fatty liver, NAFL) to non-alcoholic steatohepatitis (NASH) and cirrhosis. NAFL increases the risk of liver fibrosis. If the liver is fatty due to causes of insulin resistance such as obesity and physical inactivity, it overproduces glucose and triglycerides leading to hyperinsul...

The effect of the level of fat substitution in cakes as well as the type of fat replacer on the textural behaviour of the product was investigated by instrumental and sensory analysis. Samples, which were varying in levels (35, 65 and 100%) and types (carbohydrate or protein based) of fat substitution were subjected to a compression test and the obtained stress strain, sigmoid curves were fitte...

Objective: Control of weight gain is an important strategy in reducing the diabetes incidence. Recently, herbal drugs have been used as a complementary and alternative medicinal care. This study was conducted to determine the effect of Ferula asafoetida on weight gain, fat accumulation, liver steatosis and leptin level. Materials and Methods: All rats of control and treatment groups received d...

Mammary cancer is the most common type of cancer and the fifth most common cause of cancer-related deaths among Japanese women. The recent sharp increase in the number of women diagnosed with mammary cancer per year is thought to be associated with increased fat intake resulting from changes in the dietary habits of contemporary Japanese citizens. In this study, human c-Ha-ras proto-oncogene tr...

Numerous studies have shown the strong and independent association between fat accumulation on anatomical structures such as the mesentery and greater omentum (i.e., visceral fat accumulation) and risk factors for type 2 diabetes and cardiovascular disease [1]. This strong association suggests a close physiological link between fat cells located within the visceral fat compartments, the viscera...

background: a high-fat diet (hfd) and fat accumulation promote the oxidative stress formation, which in turn has hazardous effects on reproductive system and fertility. therefore, the present study examines the potential positive effects of a restricted high-fat diet (rhfd) and antioxidants consumption on sperm parameters in rats. methods: 48 male albino wistar rats divided to four groups (n=12...

background leptin, a protein released from adipose tissue, could have significant role in pathogenesis of obesity and type 2 diabetes mellitus. conclusions it is speculated that lower serum leptin levels in diabetic patients may be a consequence of male gender. moreover, results suggest that serum leptin level in women is influenced differently than that in men. results the serum leptin level i...

Oxyresveratrol has been proven effective in inhibiting adipogenesis in a 3T3-L1 cell model. We investigated the preventive effect of oxyresveratrol supplementation on obesity development in high-fat diet-fed mice. Male C57bl/6 mice were randomly subjected to control (5% fat by weight, LF), high-fat (30% fat by weight, HF), and high-fat supplemented with 0.25% and 0.5% oxyresveratrol (OXY1 and O...

Clock(δ19)+MEL mutant mice, which retain melatonin rhythmicity, but lack peripheral tissue rhythmicity have impaired glucose tolerance, but reduced plasma free fatty acids, increased plasma adiponectin, and improved insulin sensitivity. Here, we report their response to a high-fat diet and adipocyte rhythmicity and function. The diet increased epigonadal fat weight similarly (twofold) in both w...

BACKGROUND Fat deposition in muscle has been found to be related to metabolic risk. OBJECTIVE This study compared soleus intramyocellular lipid (IMCL) concentrations after consumption of weight-maintaining, controlled diets differing in total fat and fat type. DESIGN This study consisted of 3 phases of 25 d each in a crossover, controlled feeding design. The low-fat (LF) diet provided 30.8%...