نتایج جستجو برای: familial defective apolipoprotein

تعداد نتایج: 117246  

2009
Svetlana Sarantseva Svetlana Timoshenko Olga Bolshakova Eugenia Karaseva Dmitry Rodin Alexander L. Schwarzman Michael P. Vitek

BACKGROUND Mutations of the amyloid precursor protein gene (APP) are found in familial forms of Alzheimer's disease (AD) and some lead to the elevated production of amyloid-beta-protein (Abeta). While Abeta has been implicated in the causation of AD, the exact role played by Abeta and its APP precursor are still unclear. PRINCIPAL FINDINGS In our study, Drosophila melanogaster transgenics wer...

Journal: :The Journal of clinical investigation 1987
P W Connelly G F Maguire J A Little

A 60-yr-old woman and her brother, products of a consanquinous mating, were chylomicronemic. The chylomicronemia in both subjects was found to be due to the absence of functional apoCII. A mutant form, designated apoCIISt. Michael (apoCIIs), was identified by two-dimensional electrophoresis and Western blot using anti-apoCII antiserum. The isoelectric point of apoCIIs was similar to that of nor...

Journal: :Stroke 1985
A Postiglione P Rubba B De Simone L Patti U Cicerano M Mancini

Common and internal carotids have been studied by noninvasive method (echo-Doppler) in 30 normotensive patients with familial hypercholesterolemia (FH). Vascular lesions were detected in 14 patients (46%), who presented one or more lesions of different degree (between 1-15% and 16-49%). In one case, only one carotid had stenosis greater than 50%. Severity and number of stenosis were related to ...

Journal: :Arteriosclerosis, Thrombosis, and Vascular Biology 2000

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