When blood plasma containing the NH2-terminal 12-residue peptide (N-peptide) of alpha 2-plasmin inhibitor (alpha 2PI; alpha 2-antiplasmin) was clotted in the presence of calcium ions, the N-peptide and alpha 2PI were cross-linked to fibrin by activated coagulation factor XIII. The amount of N-peptide cross-linked to fibrin was proportional to the concentration of N-peptide present in plasma. On...

Predictions of protein structure are best tested without prior knowledge of the protein three-dimensional structure. Three-dimensional atomic models will soon be determined by X-ray crystallography for the alpha-subunit of human blood clotting factor XIII and members of the family of protein tyrosine specific phosphatases. Accordingly, we here present secondary structure predictions for each of...

Background—Mechanisms by which the Pl (Leu33Pro) polymorphism of 3 integrins could lead to an increased risk for coronary events are unclear. This study was designed to examine the effect of this polymorphism on blood coagulation. Methods and Results—In normal subjects (12 with Pl, 9 with Pl, and 3 with Pl), we evaluated the activation of prothrombin, factor V, and factor XIII and fibrinogen re...

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Comparative studies of coagulation factors in arterial and venous blood were made in 14 normal subjects and in 4 patients with arterial or ventricular septal defect. No difference was found at the level of prothrombin, factor V, factor VII/X, retraction, factor XIII, and platelet count. Fibrinogen and factor VIII were significantly low in the venous blood. The platelet count was higher in the c...

A B S T R A C T The contribution of fibrin stabilization to clot strength, measured as the static elastic modulus, was evaluated in human plasma by two independent procedures. In the first approach, amine inhibitors of fibrin stabilization were examined for their effects on the rigidity of normal plasma clots. It is a unique property of these inhibitors that they do not interfere with the rever...

Human 2-antiplasmin ( 2AP), also known as 2-plasmin inhibitor, is the major inhibitor of the proteolytic enzyme plasmin that digests fibrin. There are 2 N-terminal forms of 2AP that circulate in human plasma: a 464-residue protein with Met as the N-terminus, Met2AP, and a 452residue version with Asn as the N-terminus, Asn2AP. We have discovered and purified a proteinase from human plasma that c...

A theory is outlined that explains the disruption that occurs when auditory feedback is altered. The key part of the theory is that the number of, and relationship between, inputs to a timekeeper, operative during speech control, affects speech performance. The effects of alteration to auditory feedback depend on the extra input provided to the timekeeper. Different disruption is predicted for ...