OBJECTIVE To determine the frequency of Factor V Leiden in cases of Deep Vein Thrombosis and Healthy controls. METHODS This case control study was performed in Armed Forces Institute of Pathology Rawalpindi, From 21(st) March to 25(th) September 2013. One hundred patients with diagnostic evidence of Deep vein thrombosis on Doppler ultrasound/Magnetic resonance imaging (MRI) scan were included...

Activated protein C (APC) resistance, both in its congenital form, due to the factor V Leiden mutation, and in its acquired form, are important risk factors for systemic venous thrombosis. In view of the suspected thrombotic aetiology of some cases of recurrent miscarriage, the prevalence of APC resistance was determined among 1111 consecutive Caucasian women with a history of either recurrent ...

INTRODUCTION There are very few data assessing a family history of venous thromboembolism (VTE) as a risk factor for VTE. This question is nonetheless of interest as inherited risk factors are involved but at least partly unknown. METHODS The E.D.I.TH. study is a prospective hospital-based case-control study. The family history was assessed by using a standard questionnaire, considering the t...

BACKGROUND Previous reports on hypercoagulable factors in inflammatory bowel diseases involve heterogeneous populations and patients on various medications. AIMS To determine the frequency of thrombotic complications in ulcerative colitis (UC); to evaluate for hyperhomocysteinemia and its relationship to vitamin B12 and folate levels and methylene tetrahydrofolate reductase (MTHFR) mutation; ...

Ascending aorta and aortic arch thrombosis is rare in a young man with no risk factor. Here, we report the case of a young male patient with factor V Leiden mutation who developed ascending aorta and aortic arch thrombosis and subsequent emboli.

BACKGROUND A genetic variation located in the 3'-untranslated region of the prothrombin gene (prothrombin 20210 G-->A) was recently described as a risk factor for venous thrombosis. We examined how the presence of this mutation affected the risk of myocardial infarction in a population-based case-control study. Furthermore, we studied the risk of myocardial infarction associated with the simult...

Background and Purpose—The factor V Leiden mutation is associated with ischemic stroke in children but not in adults. Whether it is associated with ischemic stroke in young adults, however, is uncertain. Methods—To address this issue, we performed a meta-analysis of 18 case-control studies of ischemic stroke in adults 50 years of age and younger published before June 2009. Results—Across all st...

Cerebral venous thrombosis is a relatively rare, however life-threatening condition. Current studies show that around 10% of the patients die. Earlier works proved that most of the thromboses originated secondarily, as a consequence of local or systemic infection, more than 30% of the cases were considered to be idiopathic. More recent studies also mention other risk factors, which may contribu...

restriction endonuclease (3). The HFE Cys282Tyr and His63Asp mutations were detected by PCR-RFLP using the restriction endonucleases RsaI and BclI, respectively (4). Among the 100 patients with FV Leiden allele, 5 were heterozygous for the C282Y mutation, 26 were heterozygous for the H63D mutation, 2 were homozygous for the H63D mutation, and 1 was a double heterozygote for both mutations (Tabl...