The distribution of factor V Leiden G1691A, II G20210A, MTHFR C677T, and H1299R polymorphisms known to predispose thrombophilia in 215 cases 40 controls admitted with indication recurrent pregnancy loss (RPL) was investigated. Genotyping performed by melting curve analysis using simultaneous PCR (RT-PCR). There no difference between genotype allele frequencies the case control groups terms exam...

background: recurrent pregnancy loss is (rpl) a heterogeneous condition. while the role of acquired thrombophilia has been accepted as an etiology for rpl, the contribution of specific inherited thrombophilic gene polymorphisms to the disorder has been remained controversial. methods: one hundred women with a history of two or more consecutive abortions and 100 women with at least two live birt...

BACKGROUND Activated Protein C Resistance (APCR), a poor anticoagulant response of APC in haemostasis, is the commonest heritable thrombophilia. Adverse outcomes during pregnancy have been linked to APCR. This study determined the frequency of APCR, factor V gene known and novel SNPs and adverse outcomes in a group of pregnant women. METHODS Blood samples collected from 907 pregnant women wer...

APC cleavage site. The first one is a new factor V mutation associated with APC resistance (factor V Cambridge, G1091 = C mutation, Arg306 = Thr substitution). This mutation was found in a family with a strong history of thrombosis. Our group has independently described another novel mutation (A1090 = G) that results in Arg306 = Gly substitution but it is, however, not associated with APC resis...

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Background & Aims:Thromboembolism is an acute cardiovascular disease that ranges from clinically unimportant to massive embolism. Both acquired and hereditary risk factors contribute to the disease.
We aimed to determine the prevalence of two hereditary predisposing factor of the disease, prothrombin G20210A and factor V Leiden (G1691A) polymorphisms, in Kerman population.<br /...

Title: Preclinical activity of nanoliposomal irinotecan is governed by tumor deposition and intratumor pro-drug conversion Authors: *Ashish V. Kalra, *Jaeyeon Kim, Stephan G. Klinz, Nancy Paz, Jason Cain, Daryl C. Drummond, Ulrik B. Nielsen, Jonathan B. Fitzgerald Authors Affiliation: Merrimack Pharmaceuticals, Inc., Cambridge, Massachusetts Running Title: nal-IRI activity depends on CPT-11 dep...

Alexey V. Gorshkov, Tommaso Calarco, Mikhail D. Lukin, and Anders S. Sørensen Physics Department, Harvard University, Cambridge, Massachusetts 02138, USA Institut für Quanteninformationsverarbeitung, Universität Ulm, Albert-Einstein-Allee, D-89081 Ulm, Germany QUANTOP, Danish National Research Foundation Center for Quantum Optics, Niels Bohr Institute, University of Copenhagen, DK-2100 Copenhag...