Purpose – The purpose of this paper is to describe the emergence of the mobile library FabLab FryskLab, a project of Bibliotheekservice Fryslân. There will be special attention on how the business case has been established. Design/methodology/approach – The author examines the broader development of (mobile) FabLabs in libraries. Based on the description of sub-projects that together make the p...

The translocation time of poly(dT)(45) through an α-hemolysin pore was reduced in the presence of a DNA-binding Fab fragment. The Fab acts as a rudder to steer the DNA into the pore.

636 mAbs Volume 4 issue 6 Immunology and structural biology are highly complex fields of study in which mechanisms and inter-relationships are often not easily understood. It is therefore quite common to use metaphors to make knowledge gained accessible to experts and non-experts alike. Thus we, for example, all know the antibody as a Y-shaped protein with two arms and a tail and we understand ...

Honey bees, especially Apis dorsata Fab. and A. florea F., are broadly found associated with forests. Whereas, cerana indica is both in wild domesticated state. Flowers of fores...

Recent studies suggest that radioimmunotherapy (RIT) with highlinear energy transfer (LET) radiation may have therapeutic advantages over conventional low-LET (e.g., b) emissions. Furthermore, fragments may be more effective in controlling tumor growth than complete IgG. However, to the best of our knowledge, no investigators have attempted a direct comparison of the therapeutic efficacy and to...

The main difference between the two cooperative studies on therapy of childhood acute myelogenous leukemia AML-BFM-78 and AML-BFM-83 was the addition of an 8-day ADE (cytosine arabinoside, daunorubicin, etoposide) induction treatment in the second study. Due to this intensification, the relapse rate, but not the rate of induction failures, was reduced. The probability of a 6-year event-free sur...

Although antigen-binding fragments (Fabs) of antibodies constitute established tracers for in vivo radiodiagnostics, their functionality is hampered by a very short circulation half-life. PASylation, the genetic fusion with a long, conformationally disordered amino acid chain comprising Pro, Ala and Ser, provides a convenient way to expand protein size and, consequently, retard renal filtration...

Chemical conjugation of small recombinant proteins with polyethylene glycol (PEG) is an established strategy to extend their typically short circulation times to a therapeutically useful range. We have investigated the production of a genetic fusion with a glycine-rich homo-amino-acid polymer (HAP) as an alternative way to attach a solvated random chain with large hydrodynamic volume. The anti-...