The lysosomal hydrolase N-acetylgalactosamine-4-sulphatase (4-sulphatase) is essential for the sequential degradation of the glycosaminoglycans, dermatan and chondroitin sulphate and, when deficient, causes the lysosomal storage disorder mucopolysaccharidosis type VI. The cysteine at codon 91 of human 4-sulphatase was identified previously as a key residue in the active site of the enzyme and w...

The paper studies a distributed implementation method for the BIP (Behavior, Interaction, Priority) component framework for modeling heterogeneous systems. BIP offers two powerful mechanisms for describing composition of components by combining interactions and priorities. A system model is layered. The lowest layer contains atomic components; the second layer, describes possible interactions b...

Two classes of ER stress sensors are known in plants, membrane-associated basic leucine zipper (bZIP) transcription factors and RNA splicing factors. ER stress occurs under adverse environmental conditions and results from the accumulation of misfolded or unfolded proteins in the ER lumen. One of the membrane-associated transcription factors activated by heat and ER stress agents is bZIP28. In ...

In mammalian cells, most membrane proteins are inserted cotranslationally into the ER membrane at sites termed translocons. Although each translocon forms an aqueous pore, the permeability barrier of the membrane is maintained during integration, even when the otherwise tight ribosome-translocon seal is opened to allow the cytoplasmic domain of a nascent protein to enter the cytosol. To identif...

Cannabinoids, the bioactive constituents of cannabis, exert a wide array effects on brain by engaging Type 1 cannabinoid receptor (CB1R). Accruing evidence supports that action relies context-dependent factors, such as biological characteristics target cell, suggesting cell population-intrinsic molecular cues modulate CB1R-dependent signaling. Here, using yeast two-hybrid-...

Facility location selection queries help to evaluate the popularity of different facility locations for a to-be-added facility. Such queries have wide applications in marketing and decision support systems. In this report, we propose and investigate a new type of queries aiming to retrieve the top-k most influential locations from a candidate set in a given context of customers and existing fac...

The proliferation of multiand manycores creates an important design problem: the design and verification for mixed-criticality constraints in timing and safety, taking into account the resource sharing and hardware faults. In our work, we aim to contribute towards the solution of these problems by using a formal design language – the real time BIP, to model both hardware and software, functiona...

By using the notion of compatibility of subgraphs with a perfect matching developed for digraphs in [1], we show that if, in a balanced bipartite graph G of minimum degree 6, the maximum cardinality ebip of a balanced independent subset satisfies ~bip ~< 26-4, then G is hamiltonian-biconnected, and if Ctbip ~< 26-2, G contains a hamiltonian path. Moreover, we give some properties of balanced bi...