UNLABELLED We have measured complete concentration-detection (i.e., psychometric or detectability) functions to study the olfactory and ocular/nasal chemesthetic (a term that includes sensory irritation) impact of VOCs presented singly and in various binary mixtures. Such functions provide considerably more information than that provided by measuring only a "threshold". The outcome for single V...

The objective of the present study was to prepare controlled release formulation of Moxifloxacin hydrochloride ocular nanoparticles. The nanoparticles were prepared by solvent displacement method using Eudragit RL 100 as a polymer. Different formulations were prepared by varying the ratios of drug and polymer and varying the ratios of organic and aqueous phase. The formulations were evaluated i...

This paper describes a novel idea of linking models of exposure, internal dosimetry, and health effects. Risk assessment approach that integrates predicted odor caused by volatile organic compounds (VOC-odor) of toluene/xylene concentrations in human tissues leads to predict exposure risks in livestock buildings. First, VOC transport model was developed to calculate airborne toluene/xylene conc...

Background The aim of the study was to develop a sustained ocular delivery of brinzolamide (BLZ) based on gellan gum. Methods The formulations were characterized for clarity, gelling capacity, rheological studies, pH, drug content, and in vitro drug-release behavior. In vivo rabbit eye irritation test was conducted to evaluate irritation of the BLZ gel drug-delivery system. The prepared BLZ f...

A 65-year-old man developed subacute horizontal diplopia due to left abducens nerve (AN) palsy and excessive eye tearing. Brain MRI revealed a hyperintense T2 lesion with an elongated course within the carotid canal, presenting homogenous contrast enhancement (figure 1). The imaging findings were characteristic for internal artery sympathetic plexus (ICSP) schwannoma compressing AN. Subsequent ...