The complete spectrum of neuropsychiatric effects SARS-CoV-2 acute respiratory distress syndrome has yet to be fully appreciated, particularly in intubated patients. Manifestations including delirium and catatonia need considered COVID-19 Medications known exhibit neuroprotective effects, like valproate, can assist agitation related sedative withdrawal during extubation. This case series report...

Background: Early extubation is implemented in cardiothoracic units worldwide for its advantages such as decreased mortality, morbidity, and hospitalization costs. We conducted a retrospective study to evaluate potential factors which may affect extubation time. Methods: The records of 334 eligible patients who underwent elective coronary artery bypass grafting (CABG) in 2008 in Kowsar ...

BACKGROUND Non-invasive ventilation can prevent respiratory failure after extubation in individuals at increased risk of this complication, and enhanced survival in patients with hypercapnia has been recorded. We aimed to assess prospectively the effectiveness of non-invasive ventilation after extubation in patients with hypercapnia and as rescue therapy when respiratory failure develops. MET...

OBJECTIVE To determine the effects of tracheostomy on respiratory mechanics and work of breathing (WOB). DESIGN A before-and-after trial of 20 patients undergoing tracheostomy for repeated extubation failure. SETTING Surgical intensive care unit at a university teaching hospital and a level I trauma center. PATIENTS A consecutive sample of 20 patients who met extubation criteria (Pa(O2), ...

BACKGROUND Perioperative respiratory complications after adenotonsillectomy (T&A) are common and have been described to occur more frequently in children below 3 years of age, those with cranio-facial abnormalities, Down syndrome, obstructive sleep apnea, morbid obesity, and failure to thrive. AIMS To investigate the association between awake vs deep tracheal extubation and perioperative resp...

BACKGROUND While studies have suggested that prophylactic noninvasive ventilation (NIV) could prevent post-extubation respiratory failure in the intensive care unit, they appear inconsistent with regard to reintubation. We assessed the impact of a prophylactic NIV protocol on reintubation in a large population of at-risk patients. METHODS Prospective before-after study performed in the medica...

We read with interest the recently published review in Critical Care about post-extubation laryngeal edema and stridor by Pluijms et al. [1]. The review considers in detail the risk factors for post-extubation respiratory failure and describes a post-extubation algorithm for its prevention and reduction. We recently published a case report describing the occurrence of post-extubation stridor le...

OBJECTIVE The objective of this study was to evaluate the ratio of dead space to tidal volume (VD/VT) as a predictor of extubation failure of children from mechanical ventilation. METHODS From September 2001 to January 2003 we studied a cohort consisting of all children (1 day-15 years) submitted to mechanical ventilation at a pediatric intensive care unit who were extubated and for whom pre-...