Modern travel and military operations have led to a significant increase in the need to provide medical care in extreme climates. Presently, there are few data on what happens to the doctor, their drugs and equipment when exposed to these extremes. A review was undertaken to find out the effects of 'extreme heat or cold' on anaesthesia and critical care; in addition, subject matter experts were...

Introduction: Extreme weather or climate, including heat waves and cold waves, is considered a health issue causing adverse effects on health, such as cardiovascular diseases (CVDs), mortality and morbidity. Thus, this systematic review aimed to study the impacts of extreme ambient temperature on cardiovascular outcomes. Material and Methods: This study was carried out based on the Preferred R...

The structure of glucose dehydrogenase from the extreme halophile Haloferax mediterranei has been solved at 1.6-A resolution under crystallization conditions which closely mimic the "in vivo" intracellular environment. The decoration of the enzyme's surface with acidic residues is only partially neutralized by bound potassium counterions, which also appear to play a role in substrate binding. T...

Theories of semantic memory tend between two poles. At one extreme is a view often associated with the connectionist enterprise: that the semantic system is a unitary, homogeneous mass, without functional or neuroanatomic specialisation, that capitalises on statistical regularities in the environment in learning about and processing semantic information. On this account, double dissociations of...

BACKGROUND The role that environmental factors, such as neighborhood socioeconomics, food, and physical environment, play in the risk of obesity and chronic diseases is not well quantified. Understanding how spatial distribution of disease risk factors overlap with that of environmental (contextual) characteristics may inform health interventions and policies aimed at reducing the environment r...

BACKGROUND Although attention deficit hyperactivity disorder (ADHD) is thought to reflect a continuously distributed quantitative trait, it is assessed through binary diagnosis or skewed measures biased towards its high, symptomatic extreme. A growing trend is to study the positive tail of normally distributed traits, a promising avenue, for example, to study high intelligence to increase power...

Polar organisms have been found to develop unique defences against the extreme environment environment, leading to the biosynthesis of novel molecules with diverse bioactivities. This review covers the 219 novel natural products described since 2001, from the Arctic and the Antarctic microoganisms, lichen, moss and marine faunas. The structures of the new compounds and details of the source org...

Banger is a parallel programming environment used by non-professional programmers to write explicitly parallel large-grain parallel programs. The goals of Banger are: 1. extreme ease of use, 2. immediate feedback, and 3. machineindependence. Banger is based on three principles: 1. separation of parallel programming-in-the-large from sequential programming-in-the-small, 2. separation of programm...