نتایج جستجو برای: extracellular matrix metalloproteinase inducer emmprincd147

تعداد نتایج: 470331  

Journal: :Molecular biology of the cell 2000
I Yana S J Weiss

Membrane type-1 matrix metalloproteinase (MT1-MMP) is the prototypical member of a subgroup of membrane-anchored proteinases that belong to the matrix metalloproteinase family. Although synthesized as a zymogen, MT1-MMP plays an essential role in extracellular matrix remodeling after an undefined process that unmasks its catalytic domain. We now report the existence of a proprotein convertase-M...

Journal: :Reproductive Biology and Endocrinology : RB&E 2008
Keiichiro Kizaki Koichi Ushizawa Toru Takahashi Osamu Yamada Junichi Todoroki Takashi Sato Akira Ito Kazuyoshi Hashizume

BACKGROUND Various molecules participate in implantation and maintaining endometrial function during gestation. The remodeling of endometrial matrices is a necessary process in the coordination of gestational progress. Matrix-metalloproteinases (MMPs) like gelatinases (MMP-2 and -9) and collagenase (MMP-1) are considered to play important roles in this process. We examined MMP-2 and -9 expressi...

Journal: :iranian journal of basic medical sciences 0
samaneh hajihoseini hiv and hepatitis research center, faculty of laboratorial sciences, gerash, fars, iran mirza khalil bahmani hiv and hepatitis research center, faculty of laboratorial sciences, gerash, fars, iran ayyoob khosravi golestan university of medical sciences, gorgan, golestan, iran eslam ghezelsofla hiv and hepatitis research center, faculty of laboratorial sciences, gerash, fars, iran abbas ghaderi cancer research institute, shiraz university of medical sciences, shiraz, fars, iran

objective(s) matrix metalloproteinases comprise a family of enzyme that is able to degrade components of extra cellular matrix. there are single nucleotide polymorphisms in the promoter regions of several genes with ability to influence cancer susceptibility. the aim of this study was to analyses association between mmp2 and mmp9 promoter polymorphisms and head and neck squamous cell carcinoma ...

Journal: :Japanese journal of ophthalmology 1998
Y Okada T Matsuo H Ohtsuki

Bovine trabecular cells in growth phase were exposed to cyclic mechanical stretching of the bottom of a culture dish at a cycle of 30 seconds for 72 hours. The stretched cells produced significantly larger amounts of metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-1 (TIMP-1) after 72 hours, compared with cells in nonstretched control. In contrast, TIMP-2 and MMP-9 levels w...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2006
Janette K Burgess Qi Ge Maree H Poniris Sarah Boustany Stephen M Twigg Judith L Black Peter R A Johnson

Airway remodeling describes the structural changes that occur in the asthmatic airway that include airway smooth muscle hyperplasia, increases in vascularity due to angiogenesis, and thickening of the basement membrane. Our aim in this study was to examine the effect of transforming growth factor-beta on the release of connective tissue growth factor and vascular endothelial growth factor from ...

Journal: :Stroke 2006
Joost P G Sluijter Wilco P C Pulskens Arjan H Schoneveld Evelyn Velema Chaylendra F Strijder Frans Moll Jean-Paul de Vries Jan Verheijen Roeland Hanemaaijer Dominique P V de Kleijn Gerard Pasterkamp

BACKGROUND AND PURPOSE We studied matrix metalloproteinases (MMP) 2, 8, and 9 and extracellular matrix metalloproteinase inducer (EMMPRIN) levels in relation to carotid atherosclerotic plaque characteristics. METHODS Carotid atherosclerotic plaques (n=150) were stained and analyzed for the presence of collagen, smooth muscle cell (SMC), and macrophages. Adjacent segments were used to isolate ...

Journal: :American journal of physiology. Heart and circulatory physiology 2009
Balachandar Venkatesan Anthony J Valente Venkatapuram Seenu Reddy Deborah A Siwik Bysani Chandrasekar

Vascular smooth muscle cell (SMC) migration is an important mechanism in atherogenesis and postangioplasty arterial remodeling. Previously, we demonstrated that the proinflammatory cytokine interleukin (IL)-18 is a potent inducer of SMC migration. Since extracellular matrix metalloproteinase inducer (EMMPRIN) stimulates ECM degradation and facilitates cell migration, we investigated whether IL-...

Journal: :Molecular & Cellular Proteomics : MCP 2009
Arzu Umar Hyuk Kang Annemieke M. Timmermans Maxime P. Look Marion E. Meijer-van Gelder Michael A. den Bakker Navdeep Jaitly John W. M. Martens Theo M. Luider John A. Foekens Ljiljana Paša-Tolić

Tamoxifen resistance is a major cause of death in patients with recurrent breast cancer. Current clinical factors can correctly predict therapy response in only half of the treated patients. Identification of proteins that are associated with tamoxifen resistance is a first step toward better response prediction and tailored treatment of patients. In the present study we intended to identify pu...

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