During intestinal invasion, Entamoeba histolytica opens tight junctions (TJs) reflected by transepithelial electrical resistance (TEER) dropping. To explore the molecular mechanisms underlying this, we studied in vitro and in vivo the damage produced by the recombinant E. histolytica cysteine protease (rEhCP112) on TJ functions and proteins. rEhCP112 reduced TEER in Caco-2 cells in a dose- and ...

We recently diagnosed a very rare case of ulcerative pleurisy secondary to amoebiasis. The patient, a 49 year old male was admitted to Universiti Sains Malaysia Hospital complaining of shortness of breaths of a week’s duration. Clinical examinations showed features of consolidation of the right lower base and pneumonia was clinically suspected. Chest xray (Fig. 1a) showed pleural effusion and o...

Contact-dependent cytolysis of host cells by Entamoeba histolytica is an important hallmark of amoebiasis that points out the importance of molecules involved in the interaction between the parasite and the human cells. To decipher the molecular and cellular mechanisms supporting the invasion of the intestinal epithelium by E. histolytica, we analysed proteins involved in the interaction of the...

The skin and mucosal epithelia of humans and other mammals are permanently colonized by large microbial communities (the microbiota). Due to this life-long association with the microbiota, these microbes have an extensive influence over the physiology of their host organism. It is now becoming apparent that nearly all tissues and organ systems, whether in direct contact with the microbiota or i...

Crohn's disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract. Patients with this disease have an increased risk for both intestinal and various extra-intestinal malignancies. This risk is mainly attributed to chronic inflammation and druginduced immunosuppression. Various extra-intestinal malignancies, such as lymphoproliferative disorders and non-melanoma skin cancers ...

Objective: To assess the magnitude of Entamoeba histolytica/ Entamoeba dispar infestation and to study some socio-demographic correlates in relation to parasitic infestation in the study subjects. Material & Methods: A cross sectional epidemiological study was carried out in West Bengal, India among rural population of two districts. Stool samples from selected study subjects of all age groups ...

Abstract Gastrointestinal mucosa forms a surface that interacts with many external factors. Beside the digestion and absorption of nutrients, it also acts as barrier to allergens, pathogens, toxins. Leaky gut syndrome is defined mucosal dysfunction, which results in abnormally increased intestinal permeability. Research shows leaky (LGS) has pathogenetic relationship series gastrointestinal ext...