BACKGROUND The clinical activities of all-trans retinoic acid in the treatment of acute promyelocytic leukemia, a unique subtype of acute myeloid leukemia, have triggered extensive studies aimed at defining the mechanisms by which this compound induces differentiation of leukemic cells. Recent studies show that hypoxia-inducible factor-1 alpha (HIF-1 alpha) contributes to the differentiation of...

As the Service-oriented architecture paradigm has become ever more popular, different standardization efforts have been proposed by various consortia to enable interaction among heterogeneous environments through this paradigm. This chapter will overview the most prevalent of these SOA Efforts. It will first show how technical services can be described, how they can interact with each other and...

introduction although thyroid nodules are usually benign, malignancy must always be ruled out. many efforts have been made to find. malignant nodules and reduce the number of unnecessary operations. in this study, our aim was to examine, after the more extensive use of fine needle aspiration (fna), whether the incidence of cancer finding has been increased. materials and methods we studied retr...

abstract: following the failure of the combatants in operation karbala-4 and in despite of the various problems which existed for launching the next operation, operation karbala-5 necessarily began in shalamcheh area in jan. 1987. an exclusive and very important operation included many experiences in different aspects, particularly be cause both sides had been entered into the scene with all of...

MOTIVATION In the developing nervous system, the expression of proneural genes, i.e. Hes1, Neurogenin-2 (Ngn2) and Deltalike-1 (Dll1), oscillates in neural progenitors with a period of 2-3 h, but is persistent in post-mitotic neurons. Unlike the synchronization of segmentation clocks, oscillations in neural progenitors are asynchronous between cells. It is known that Notch signaling, in which N...

amyloid-β (aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in alzheimer’s disease pathology.uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...

Objective: Most of the research conducted so far on effective treatments for social anxiety disorder has used traditional cognitive-behavioral therapies. However, recent pathological theories emphasize the role of emotion regulation in the formation and continuation of the symptoms of this disorder. Thus, the study has been conducted to compare the efficacy of emotion- oriented therapy and the ...

Severe physical activity leads to a sharp increase in free radicals, an oxidative stress, inflammation, and tissue damage. Resveratrol as one of the antioxidants can be effective in preventing the effects of oxidative stress. Therefore, the present study was aimed to evaluate the effect of trans-resveratrol supplementation and training exercise on inflammation-related factors. Sixty-four ...