objective(s) resistance to the new generation of cephalosporins which is mediated by extended-spectrum beta-lactamases (esbls) has been found among escherichia coli isolates throughout the world. these resistance genes and their producers, the micro-organisms carrying beta-lactamases, are responsible for serious clinical and therapeutic problems among inpatients and it is necessary to pay more ...

CONTEXT The CTX-M family consists of more than 50 β-lactamases, which are grouped on the basis of sequences into five subtypes including CTX-M-1, CTX-M-2, CTX-M-8, CTX-M-9 and CTX-M-25. OBJECTIVES The current study aimed to detect subtypes of CTX-M extended-spectrum β-lactamases (ESBLs) among ESBL positive Klebsiella isolates from patients in Kashan, Iran. MATERIALS AND METHODS A total of 1...

Early diagnosis and probabilistic antibiotic therapy based on known bacterial ecology sensibility can reduce mortality morbidity in pathologies caused by a infection. This study aimed at determining the prevalence risk factors of extended-spectrum β-lactamases (ESBLs)-producing Escherichia coli isolated from blood cultures neonates infants population. We conducted cross-sectional during which p...

INTRODUCTION While the Clinical and Laboratory Standards Institute (CLSI) recommends against routine screening for extended spectrum β-lactamases (ESBLs), knowledge of these data can provide valuable insights regarding epidemiology and drug therapy decisions. The purpose of this study was to compare the impact of minimum inhibitory concentration (MIC)-based screening versus phenotypic confirmat...

BACKGROUND & OBJECTIVES AmpC β-lactamases are clinically significant since these confer resistance to cephalosporins in the oxyimino group, 7-α methoxycephalosporins and are not affected by available β-lactamase inhibitors. In this study we looked for both extended spectrum β-lactamases (ESBL) and AmpC β-lactamases in Klebsiella pneumoniae clinical isolates. METHODS One hundred consecutive, n...

Salmonella serovar Typhimurium is a leading cause of food-borne diseases worldwide. Its ability to acquire new antibiotic resistance mechanisms is of increasing therapeutic concern [1]. CTX-M betalactamases are the most common extended spectrum β-lactamases (ESBLs) worldwide [2]. The first report of CTX-M detection in Salmonella was in a Tunisian outbreak caused by Salmonella enterica serovar W...

The occurrence of multidrug-resistant Serratia marcescens strains producing metallo-β-lactamases or extended-spectrum β-lactamases represents a serious public health threat. Here, we report the draft genome sequence of a multidrug-resistant carbapenemase-producing Serratia marcescens isolate recovered from the bronchoalveolar lavage specimen of a patient suffering from chronic obstructive pulmo...

Urinary tract infections (UTIs) are a stern public health problem and are caused by a wide range of pathogens, but most frequently by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecalis and Staphylococcus saprophyticus. High frequency rates and increasing antimicrobial resistance among uropathogens threaten to greatly raise the economic load of these infections. Fe...