BACKGROUND The term "exposome" was originally coined in 2005 and defined as the totality of exposures throughout the lifetime. The exposome provides an excellent scientific framework for studying human health and disease. Recently, it has been suggested that how exposures affect our biology and how our bodies respond to such exposures should be part of the exposome. OBJECTIVES The authors des...

Cohort studies of adverse reproductive effects of occupational exposures that compare the outcome of exposed pregnancies with non-exposed pregnancies among the same group of mothers (internal controls) and among a different group of mothers (external controls) have been reviewed. Confounding of the hypothesised associations by parental characteristics, the outcome of previous pregnancies, and o...

HIV pre-exposure prophylaxis trials with antiretroviral drugs have been variably successful. Even trials demonstrating the best efficacy leave room for improvement. Pharmacological data illuminate several sources of outcome variability, especially the impact of poor adherence, which is critical to manage PrEP in the clinic and to develop the next generation of PrEP candidates.

Psychological stressors are social and physical environmental circumstances that challenge the adaptive capabilities and resources of an organism. These circumstances represent an extremely wide and varied array of different situations that possess both common and specific psychological and physical attributes. The challenge for theory, research, and practice is to abstract and understand the s...

Although transgender women have been included in HIV prevention pre-exposure prophylaxis studies, no pre-exposure prophylaxis study has focused exclusively on transgender persons. Drawing on the cardinal principles of ethics espoused in the Belmont Report, this work highlights, among other issues, that (1) the principle of Justice requires the HIV prevention field to focus exclusively on transg...

Malignant mesothelioma is an uncommon but rapidly fatal disease for which the principal aetiological agent is exposure to asbestos. Mesothelioma is of particular significance in Australia where asbestos use was very widespread from the 1950s until the 1980s. Exposure to asbestos includes occupational exposure associated with working with asbestos or in workplaces where asbestos is used and also...