earlier studies reported the existence of E1 and E2 enzymes within mitochondria (Magnani et al, 1991; Schwartz et al, 1992). In addition, a more recent and growing body of evidence shows that mitochondria also contain specific E3 ligases with a prominent role in the regulation of mitochondrial dynamics. In particular, Mitol/ March5—a ubiquitin E3 ligase embedded in the outer membrane— participa...

Games have always been popular testbeds for Artificial Intelligence (AI). In the last decade, we have seen the rise of the Multiple Online Battle Arena (MOBA) games, which are the most played games nowadays. In spite of this, there are few works that explore MOBA as a testbed for AI Research. In this paper we present and discuss the main features and opportunities offered by MOBA games to Game ...

The institutions seek to improve their performance and quality of service, so that their patients are satisfied. This research project aims, conduct a time study program in the area of gynecological surgery, to determine the current level of capacity and optimize the programming time in order to adequately respond to demand. The system is analyzed by waiting lines and uses the simulation using ...

This paper presents a research conducted over the increasing dangers of cyberterrorism. It discusses the cyberterrorism parameters the cyberterrorists, the attacks, and the countermeasures – as well as the Internet’s physical security. The paper sounds an alarm over the current accessibility of critical intranets via the Internet, and points out that the risks in this practice outweigh any poss...

While preparing this paper, I pondered what a scientist’s perspective should be. Although I no longer work at the bench, I am closely involved in the continuum of scientific research through technology to its application, and especially in its transfer to developing countries. I will briefly consider six aspects of science and end with a challenge: to come up with new proposals for action. How ...

Civil engineering structures are part of our cultural heritage. The story of who we are can be told, in part, by what we have built. There have been pivotal moments in civil engineering design history wherein a master engineer creates a pioneering structure. One major example is Anton Tedesko’s 1936 Hershey Ice Arena, the first large-scale thin shell concrete roof in the United States. Tedesko ...

Environmental enrichment (EE) is widely used in the life sciences to study effects of environment on the brain. In pigs, despite lack of EE being a key welfare issue there is little understanding of brain effects of EE in pigs. This project aimed to study the effects of exposure to an EE arena on piglet behaviours and on brain gene expression levels with a focus on IGF-1 and related genes. Eigh...

To investigate the spatial and behavioral correlates of striatal neurons during displacement movements, the rostromedial dorsal striata (AP 1.0-2.2, ML 1.5-2.0) of five rats were surgically implanted with advanceable bundles of fine wire electrodes. After recovery, the rats were deprived of water and trained in a square-walled open field in a dark room. The behavioral task required alternating ...