نتایج جستجو برای: exosome

تعداد نتایج: 3188  

2014
Ling Zhu Kun Wang Jian Cui Huan Liu Xiangli Bu Huailei Ma Weizhi Wang He Gong Christopher Lausted Leroy Hood Guang Yang Zhiyuan Hu

Exosomes are endosome-derived membrane vesicles carrying proteins and nucleic acids that are involved in cellular functions such as intercellular communication, protein and RNA secretion, and antigen presentation. Therefore, exosomes serve as potential biomarkers for many diseases including cancer. Because exosomes are difficult to enrich or purify from biofluids, quantification of exosomes is ...

Journal: :RNA 2016
Michal Domanski Paula Upla William J Rice Kelly R Molloy Natalia E Ketaren David L Stokes Torben Heick Jensen Michael P Rout John LaCava

As a result of its importance in key RNA metabolic processes, the ribonucleolytic RNA exosome complex has been the focus of intense study for almost two decades. Research on exosome subunit assembly, cofactor and substrate interaction, enzymatic catalysis and structure have largely been conducted using complexes produced in the yeast Saccharomyces cerevisiae or in bacteria. Here, we examine dif...

Journal: :Cancer research 2010
Irina Nazarenko Sanyukta Rana Alexandra Baumann Jessica McAlear Andrea Hellwig Michael Trendelenburg Günter Lochnit Klaus T Preissner Margot Zöller

Tumor-derived exosomes containing the tetraspanin Tspan8 can efficiently induce angiogenesis in tumors and tumor-free tissues. However, little information exists on exosome-endothelial cell (EC) interactions or the proangiogenic role of tetraspanins, which are a constitutive component of exosomes. In this study, we used a rat adenocarcinoma model (AS-Tspan8) to explore the effects of exosomal T...

Journal: :Journal of cell science 2009
Søren Lykke-Andersen Ditlev E Brodersen Torben Heick Jensen

The exosome is a multi-subunit 3'-5' exonucleolytic complex that is conserved in structure and function in all eukaryotes studied to date. The complex is present in both the nucleus and cytoplasm, where it continuously works to ensure adequate quantities and quality of RNAs by facilitating normal RNA processing and turnover, as well as by participating in more complex RNA quality-control mechan...

2016
Yulin Sun Weiwei Zheng Zhengguang Guo Qiang Ju Lin Zhu Jiajia Gao Lanping Zhou Fang Liu Yang Xu Qimin Zhan Zhixiang Zhou Wei Sun Xiaohang Zhao

Tumor-derived exosomes are important for cell-cell communication. However, the role of TP53 in the control of exosome production in colorectal cancer (CRC) is controversial and unclear. The features of exosomes secreted from HCT116 TP53-wild type (WT), TP53-knockout (KO) and constructed TP53 (R273H)-mutant (MT) cells were assessed. The exosomes from the MT and KO cells exhibited significantly r...

Journal: :Molecular biology of the cell 2009
Amy C Graham Daniel L Kiss Erik D Andrulis

Exosome complexes are 3' to 5' exoribonucleases composed of subunits that are critical for numerous distinct RNA metabolic (ribonucleometabolic) pathways. Several studies have implicated the exosome subunits Rrp6 and Dis3 in chromosome segregation and cell division but the functional relevance of these findings remains unclear. Here, we report that, in Drosophila melanogaster S2 tissue culture ...

Journal: :Arthritis Research 2002
Rick Brouwer Wilma TM Vree Egberts Gerald JD Hengstman Reinout Raijmakers Baziel GM van Engelen Hans Peter Seelig Manfred Renz Rudolf Mierau Ekkehard Genth Ger JM Pruijn Walther J van Venrooij

The autoantigenic polymyositis/scleroderma (PM/Scl) complex was recently shown to be the human homologue of the yeast exosome, which is an RNA-processing complex. Our aim was to assess whether, in addition to targeting the known autoantigens PM/Scl-100 and PM/Scl-75, autoantibodies also target recently identified components of the PM/Scl complex. The prevalence of autoantibodies directed to six...

2017
Paola Di Bonito Chiara Chiozzini Claudia Arenaccio Simona Anticoli Francesco Manfredi Eleonora Olivetta Flavia Ferrantelli Emiliana Falcone Anna Ruggieri Maurizio Federico

We recently proved that exosomes engineered in vitro to deliver high amounts of HPV E7 upon fusion with the Nefmut exosome-anchoring protein elicit an efficient anti-E7 cytotoxic T lymphocyte immune response. However, in view of a potential clinic application of this finding, our exosome-based immunization strategy was faced with possible technical difficulties including industrial manufacturin...

2017
Rosario Maroto Yingxin Zhao Mohammad Jamaluddin Vsevolod L. Popov Hongwang Wang Madumali Kalubowilage Yueqing Zhang Jonathan Luisi Hong Sun Christopher T. Culbertson Stefan H. Bossmann Massoud Motamedi Allan R. Brasier

Background: Extracellular vesicles contain biological molecules specified by cell-type of origin and modified by microenvironmental changes. To conduct reproducible studies on exosome content and function, storage conditions need to have minimal impact on airway exosome integrity. Aim: We compared surface properties and protein content of airway exosomes that had been freshly isolated vs. those...

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