نتایج جستجو برای: exogenous melatonin

تعداد نتایج: 61774  

Journal: :World journal of gastroenterology 2005
Mukaddes Esrefoglu Mehmet Gül Memet-Hanifi Emre Alaattin Polat Mukadder-Ayse Selimoglu

AIM To investigate the role of oxidative injury and the effect of exogenous melatonin administration on liver damage induced by bile duct ligation (BDL), and second, to evaluate the role of nitric oxide (NO), a free oxygen radical, in oxidative injury. METHODS Thirty-two Sprague-Dawley rats were assigned to four groups: sham operation (SO), BDL, BDL+melatonin, and BDL+vehicle. Cholestasis was...

2017
Agnieszka Kobylińska Russel J. Reiter Malgorzata M. Posmyk

Melatonin was discovered in plants more than two decades ago and, especially in the last decade, it has captured the interests of plant biologists. Beyond its possible participation in photoperiod processes and its role as a direct free radical scavenger as well as an indirect antioxidant, melatonin is also involved in plant defense strategies/reactions. However, the mechanisms that this indole...

2010
Tharwat S Kandil Amany A Mousa Ahmed A El-Gendy Amr M Abbas

BACKGROUND Gastro-Esophageal Reflux Disease (GERD) defined as a condition that develops when the reflux of stomach contents causes troublesome symptoms and/or complications. Many drugs are used for the treatment of GERD such as omeprazole (a proton pump inhibitor) which is a widely used antiulcer drug demonstrated to protect against esophageal mucosal injury. Melatonin has been found to protect...

Journal: :Peptides 2002
C Fernández Alvarez L Debeljuk E Díaz Rodríguez B Díaz López

Mammalian neurokinin A (NKA) and substance P (SP) are neuropeptides widely distributed in the body; they are potential regulators of the basal blood flow and therefore of the function of many organs and tissues. In the present investigation, we studied the age-dependent changes in NKA and SP in ovary, liver, pancreas and spleen as well as the role of exogenous melatonin on these changes. Female...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2008
Hiroko Ono Yuta Hoshino Shinobu Yasuo Miwa Watanabe Yusuke Nakane Atsushi Murai Shizufumi Ebihara Horst-Werner Korf Takashi Yoshimura

Local thyroid hormone catabolism within the mediobasal hypothalamus (MBH) by thyroid hormone-activating (DIO2) and -inactivating (DIO3) enzymes regulates seasonal reproduction in birds and mammals. Recent functional genomics analysis in birds has shown that long days induce thyroid-stimulating hormone production in the pars tuberalis (PT) of the pituitary gland, which triggers DIO2 expression i...

Journal: :Journal of pineal research 2006
M Rosa Nogués Montserrat Giralt Marta Romeu Miquel Mulero Vanesa Sánchez-Martos Esperanza Rodríguez Darío Acuña-Castroviejo Jordi Mallol

It has been suggested that oxidative stress is a feature of aging. The goal of the present study was to assess the oxidant effects related to aging and the protective role of exogenous melatonin in senescence-accelerated mice (SAMP8). Two groups of SAMP8 mice (males and females) were compared with their respective control groups of SAMR1 mice (senescence-resistant inbred strain) to determine th...

Journal: :Molecules 2017
Feifei Yang Changjiu He Xuyang Sun Jing Wang Can Luo Guoshi Liu Liguo Yang Jiajun Xiong Lijun Huo

Melatonin (MLT) plays an important role in regulating the physiological cycle of seasonal breeding animals. Melatonin receptor I (MT1) is effectively expressed in the cambium layer of deer antler. However, the function and metabolic mechanism of MLT/MT1 signaling in the mesenchymal cells of sika deer remain to be further elucidated. In this work, we detected the effects of MLT/MT1 signaling on ...

2002
Paul Pévet

Melatonin (MEL) is a hormone synthesized and secreted by the pineal gland deep within the brain in response to photoperiodic cues relayed from the retina via an endogenous circadian oscillator within the suprachiasmatic nucleus in the hypothalamus. The circadian rhythm of melatonin production and release, characterized by nocturnal activity and daytime quiescence, is an important temporal signa...

2013
Antonio Bellastella Annamaria De Bellis Giuseppe Bellastella Katherine Esposito

Some environmental factors may influence the pituitary-gonadal function. Among these, light plays an important role in animals and in humans. The effect of light on the endocrine system is mediated by the pineal gland, through the modulation of melatonin secretion. In fact, melatonin secretion is stimulated by darkness and suppressed by light, thus its circadian rhythm peaks at night. Light pla...

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