نتایج جستجو برای: exhausted cd4 t cell
تعداد نتایج: 2183294 فیلتر نتایج به سال:
Abstract People living with HIV have high burdens of chronic lung disease, cancers, and pulmonary infections despite antiretroviral therapy (ART). The rates tobacco smoking by people vastly exceed that the general population. Furthermore, we showed can persist within mucosa long-term ART. As CD8 T cell cytotoxicity is pivotal for controlling viral eliminating defective cells, explored phenotypi...
Abstract Background: Oral squamous cell carcinoma (OSCC) is the most frequent type of oral cancer. The tumor microenvironment OSCC induces an alteration T lymphocyte, promoting exhausted phenotype. main organelle metabolism mitochondrion and in recent years it has been indicated that several cells have capacity to transfer mitochondria, including cancer cells. However, not evaluated whether mit...
Human immunodeficiency virus (HIV)-specific CD4(+) T cell cytokine secretion is characteristically weak during HIV infection, in part because HIV-specific CD4(+) T cells undergo massive apoptotic deletion. Glucocorticoid-induced tumor necrosis factor (TNF) receptor family-related (GITR) protein triggering enhances murine antigen-specific T cell cytokine secretion by protecting T cells from apop...
As perinatally HIV-1-infected children grow into adolescents and young adults, they are increasingly burdened with the long-term consequences of chronic HIV-1 infection, with long-term morbidity due to inadequate immunity. In progressive HIV-1 infection in horizontally infected adults, inflammation, T cell activation, and perturbed T cell differentiation lead to an "immune exhaustion", with dec...
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