Clopidogrel has significantly reduced the incidence of recurrent atherothrombotic events in patients with acute coronary syndrome (ACS) and in those undergoing percutaneous coronary intervention (PCI). However, recurrence events still remain, which may be partly due to inadequate platelet inhibition by standard clopidogrel therapy. Genetic polymorphisms involved in clopidogrel's absorption, met...

AIM To review evidence supporting pharmacological treatments for treatment-resistant depression (TRD) and to discuss them according to personal clinical experience. METHODS Original studies, clinical trials, systematic reviews, and meta-analyses addressing pharmacological treatment for TRD in adult patients published from 1990 to 2013 were identified by data base queries (PubMed, Google Schol...

Evidence-Based Practice (EBP) represents a decision-making process centered on justifications of relevant information contained scientific research proof found in the Internet. Context is a type of knowledge that supports identifying what is or is not relevant in a given situation. Therefore, the integration of evidence and context is still an open issue. Besides, EBP procedures do not provide ...

Fact verification aims to evaluate the authenticity of a given claim based on evidence sentences retrieved from Wikipedia articles. Existing works mainly leverage natural language inference methods model semantic interaction and evidence, or further employ graph structure capture relation features between multiple evidences. However, previous have limited representation ability in encoding comp...

the person, who, on his way, encounters a fruit-bearing tree belonging to others, can eat from its fruit as much as fulfilling his need, provided that his reaching to that tree has been accidental rather than on purpose; and that he should not take away any fruit with him and damage a tree or a fruit. in this respect, the owner’s consent is not considered a sine qua non. the reason for this rul...

This study investigates the efficacy of say-on-pay (SOP) regulation in mitigating excessive CEO compensation and how it is affected by personal traits power distribution inside a corporation. Using IV-GMM method sample 1,931 firms from Australia, Canada, UK, USA, we find that shareholder voices are successful reducing pay gap between CEOs median employee, regardless exact nature regulation. In ...

In this article we present the second part of our historical survey on quantum Monte Carlo methods. IWe focus simulations performed at a finite temperature and based path-integral formulation mechanics. We introduce method insist central role played by description transition to superfluidity for Helium 4.

Evidences of delivery are essential for resolving (and avoiding) disputes on delivery of messages, in classical as well as electronic commerce. We present the first rigorous specifications and provably-secure implementation, for a communication layer providing time-stamped evidences for the message delivery process. This improves on existing standards for evidences (‘non-repudiation’) services,...