Deoxynivalenol (DON) is a common Fusarium toxin in poultry feed. Chickens are more resistant to the adverse impacts of deoxynivalenol (DON) compared to other species. In general, the acute form of DON mycotoxicosis rarely occurs in poultry flocks under normal conditions. However, if diets contain low levels of DON (less than 5 mg DON/kg diet), lower productivity, impaired immunity and higher su...

This paper owes much, both directly and indirectly, to Don Walker. Indirectly, it concerns a topic which was of great interest to both of us, and which we often discussed. Don helped me to clarify my own ideas and was always both perceptive and practical, a rare combination which made discussion with him constantly illuminating. There is also a direct debt; it was written at a time when I was h...

Glutaminase is a metabolic enzyme responsible for glutaminolysis, a process harnessed by cancer cells to feed their accelerated growth and proliferation. Among the glutaminase isoforms, human kidney-type glutaminase (KGA) is often upregulated in cancer and is thus touted as an attractive drug target. Here we report the active site inhibition mechanism of KGA through the crystal structure of the...

Seed-based pigeon diets could be expected to result in exposure of pigeons to mycotoxins such as deoxynivalenol (DON). Ingestion of low to moderate contamination levels of DON may impair intestinal health, immune function and/or pathogen fitness, resulting in altered host-pathogen interactions and thus different outcome of infections. Here we demonstrate that DON was one of the most frequently ...

This study investigated the growth and immune responses of pigs fed diets containing reduced concentrations of aflatoxin (AF) and deoxynivalenol (DON) from naturally contaminated corn. Sixty gilts (13.9 ± 0.2 kg of BW) were randomly assigned to 4 treatments (5 replicate pens per treatment and 3 pigs per pen): A (a control diet without detectable AF and DON); B (a diet with 60 μg of AF/kg and 30...

fusarium culmorum which is considered as the causal agent of fusarium head blight, can produce deoxynivalenol (don), nivalenol (niv) and their acetylated derivatives. this study has been assessed in order to detect the tri13 gene using primer pairs tri13donr/tri13f and tri13r/tri13nivf, to investigate the potential of f. culmorum isolates in the production of don and niv in west azarbayjan prov...