UNLABELLED Recent evidence implicates the insulin-like growth factor (IGF) pathway in development of Ewing sarcoma, a highly malignant bone and soft-tissue tumor that primarily affects children and young adults. Despite promising results from preclinical studies of therapies that target this pathway, early-phase clinical trials have shown that a significant fraction of patients do not benefit, ...

BACKGROUND Ewing sarcoma is the second most common bone tumor, occurring mainly in children and young adults. It shows a typical primitive, small round cell morphology and a characteristic fusion oncogene involving EWSR1 and members of the ETS family in most of the cases. Neuronal maturation after chemotherapy is a rare phenomenon and we herein describe such an exceptional case. CASE PRESENTA...

Ewing sarcoma (ES) and primitive peripheral neuroectodermal tumor (PNET) were originally described as distinct clinicopathologic entities by James Ewing in 1921 and Stout in 1918 respectively. At present, it is known that these entities comprise the same spectrum of tumours known as the Ewing sarcoma family of tumors (EFT) [1], which also includes malignant round-cell tumor of the thoracopulmon...

PURPOSE Ewing sarcoma is an aggressive sarcoma and is the second most common bone sarcoma in childhood. Disease-specific t(11;22) ( approximately 85-90%), t(21;22) ( approximately 5-10%), or rarer variant translocations with the involvement of chromosome 22 ( approximately 5%) are present. At the gene level, the EWSR1 gene fuses with FLI1, ERG, or other ETS transcription factor family members. ...

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A 34-year-old man presented with dyspnea, cough, and vertigo for 3 months, and persistent backache for 9 months. He was febrile and pale with no organomegaly. Blood examination revealed hemoglobin, 8.7 g/dL; white blood cell count, 11.3×10 9 /L; and platelet...

The Ewing sarcoma protein (EWS) is a well-known player in cancer biology for the specific translocations occurring in sarcomas. The EWS-FLI1 gene fusion is the prototypical translocation that encodes the aberrant, chimeric transcription factor, which is a landmark of Ewing tumors. In all described Ewing sarcoma oncogenes, the EWS RNA binding domains are completely missing; thus RNA binding prop...

Ewing sarcoma is a bone and soft-tissue tumor that depends on the activity of the EWS-FLI1 transcription factor for cell survival. Although a number of compounds have been shown to inhibit EWS-FLI1 in vitro, a clinical EWS-FLI1-directed therapy has not been achieved. One problem plaguing drug development efforts is the lack of a suitable, non-invasive, pharmacodynamic marker of EWS-FLI1 activit...

Many species of Drosophila have courtship displays in which the male vibrates one or both wings after approaching the female. In Drosophila melanogaster the major part of this display occurs with the wing nearer the female extended to nearly 90 from the long axis, in which position the wing is vibrated (Spieth, 1952). It has been shown that this vibration is accompanied by a train of sound puls...

OBJECTIVES Three patients with Ewing sarcomas showing extensive neural differentiation are presented. METHODS The patients were two women and one man between the ages of 15 and 35 years. Anatomically, one tumor was in the lung, one in the testis, and one in the cervix uteri. The symptoms were determined by the location of the neoplasm and included respiratory symptoms, testicular pain, and pe...

BACKGROUND Renal Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) is extremely rare. Clinical symptoms are nonspecific presenting abdominal pain, palpable mass, and hematuria. Owing to advanced technology demonstrating the ES-specific EWS/ETS translocation, this differential diagnosis has become feasible. PATIENTS AND METHODS The German database of GPOH Ewing's sarcoma trials from 19...