BACKGROUND Frailty is associated with morbidity and premature mortality among elderly HIV-uninfected adults, but the determinants and consequences of frailty in HIV-infected populations remain unclear. We evaluated the correlates of frailty, and the impact of frailty on mortality in a cohort of aging injection drug users (IDUs). METHODS Frailty was assessed using standard criteria among HIV-i...

BACKGROUND The level of frailty in the older population across age cohorts and how this changes is a factor in determining future care costs and may also influence the extent of socioeconomic and gender inequalities in frailty. METHODS We model cohort-specific trajectories in frailty among the community dwelling population older than 50 years, using five waves (2002-2010) of the English Longi...

OBJECTIVES to evaluate the association between dehydroepiandosterone (DHEA) and physical frailty in older adults. DESIGN cross-sectional analysis of baseline information from three separate studies in healthy older men, women and residents of assisted living. SETTING academic health centre in greater Hartford, CT, USA. PARTICIPANTS eight hundred and ninety-eight adults residing in the com...

BACKGROUND Frail health in old age has been conceptualized as a loss of physiologic reserve associated with loss of lean mass, neuroendocrine dysregulation, and immune dysfunction. Little work has been done to define frailty and describe the underlying pathophysiology. METHODS Frailty status was defined in participants of the Cardiovascular Health Study (CHS), a cohort of 5,201 community-dwel...

OBJECTIVE We tested the hypothesis that brain pathology is associated with the rate of progression of physical frailty in older adults. METHODS A total of 791 older adults participating in the Religious Orders Study and Memory and Aging Project had annual clinical evaluations from which a previously established composite measure of physical frailty was derived and brain autopsy after death. A...

BACKGROUND Understanding and addressing the needs of frail persons is an emerging health priority for Nova Scotia and internationally. Primary healthcare (PHC) providers regularly encounter frail persons in their daily clinical work. However, routine identification and measurement of frailty is not standard practice and, in general, there is a lack of awareness about how to identify and respond...

In this paper, we obtained some bounds for moments of order statistics from an arbitrary continuous probability distribution. This study considers a robust properties of correlated frailty models. The dependence between related individuals must be considered in order to be studied the difference between the gene information and the environment as causes of death. To do that, we can introduce th...

We aimed to determine whether frailty, a validated geriatric construct of increased vulnerability to physiologic stressors, predicts mortality in liver transplant candidates. Consecutive adult outpatients listed for liver transplant with laboratory Model for End-Stage Liver Disease (MELD) ≥ 12 at a single center (97% recruitment rate) underwent four frailty assessments: Fried Frailty, Short Phy...