A phenolic amine compound, 4-S-cysteaminylphenol (4-S-CAP), is a potent depigmenting agent. To develop more efficacious antimelanoma agents, we synthesized four homologues of 4-S-CAP: N-acetyl-4-S-CAP (N-Ac-4-S-CAP), alpha-methyl-4-S-CAP, 4-S-homo-CAP, and N,N'-dimethyl-4-S-CAP. We tested these five compounds in mice in vivo. After s.c. or i.p. injection of saline solution (in control groups) o...

The first broad program of scientific shallow drilling on the U.S. Atlantic continental shelf has delineated rocks of Pleistocene to Late Cretaceous age, including phosphoritic Miocene strata, widespread Eocene carbonate deposits that serve as reflective seismic markers, and several regional unconformities. Two sites, off Maryland and New Jersey, showed light hydrocarbon gases having affinity t...

Raman spectroscopy plays a major role in robust detection of biomolecules and mineral signatures in halophile research. An overview of Raman spectroscopic investigations in halophile research of the last decade is given here to show advantages of the approach, progress made as well as limits of the technique. Raman spectroscopy is an excellent tool to monitor and identify microbial pigments and...

Algal biorefinery process utilizes every component of algal biomass to produce multiple useful fuel products. In this technique, acid pretreatment of algal biomass hydrolyzes microalgal carbohydrates into fermentable sugars, makes lipids more extractable and a protein part accessible for additional products. In the present study, Chlorella sorkiniana produced higher quantity of biodiesel than B...

The Jbel Haïmer copper-sulphide mineralisation occurs at 20 km north of Marrakesh in the Variscan Jebilet massif, Morocco. Most ores (up to 3.9 wt% Cu, ?38 ppm Ag, and up 2.9 Au) occur as impregnations NE-SW fault/fracture zones related tectonic breccia. Two independent stages fluid circulation mineral deposition are distinguished. First, Late high temperature-low pressure metamorphism synchron...

Abstract The Ediacaran Period witnessed major environmental change and an expansion of eukaryotic life following the Marinoan glaciation. Doushantuo Formation south China has furnished much our understanding Earth System biosphere evolution during this period, but its depositional setting–marine or non-marine–is still debated. Here we conduct mineralogical, petrographic geochemical analyses sam...

Background: Negative regulatory mechanisms of ROCK signaling are poorly understood. We have discovered a novel mechanism to attenuate ROCK signaling. Results: Coronin1B is a novel binding partner of ROCK2 that inhibits ROCK signaling to myosin. Conclusion: Coronin1B regulates ROCK by a novel signal attenuation mechanism. Significance: Coronin1B attenuation of ROCK signaling is associated with N...