N Engl J Med 2003;349:975-86. Copyright © 2003 Massachusetts Medical Society. rug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences. Addictive substances induce pleasant states (euphoria in the initiation phase) or relieve distress. Continued use induces adaptive changes in the central nervous syst...

BACKGROUND AND OBJECTIVE Given the dual public health challenges of undertreated pain and opioid abuse, there is a need to reduce attractiveness of opioid analgesics to drug abusers. ALO-01 (morphine sulfate and naltrexone hydrochloride) extended-release capsules, indicated for treatment of chronic, moderate to severe pain, contain polymer-coated pellets of morphine, each with a core of sequest...

Opioids selective for the G protein-coupled mu opioid receptor (MOR) produce potent analgesia and euphoria. Heroin, a synthetic opioid, is considered one of the most addictive substances, and the recent exponential rise in opioid addiction and overdose deaths has made treatment development a national public health priority. Existing medications (methadone, buprenorphine, and naltrexone), when c...

Starting in the 60s and 70s, the potentials of computer use for scientists and urban planners in the upcoming years with Planning Support Systems (PSS) was considered very promising. After a time of euphoria, the following years had been a disillusionment of this prediction, however starting in the recent years, the circumstances changed dramatically. Cities are full of ubiquitous information t...

BACKGROUND: Opioid abuse has been an increasing problem since the 1990s. With over 47,000 opioid related deaths recorded in 2017 alone, concerns have raised regarding dangers of introducing opioids perioperatively to patients undergoing major surgeries. OBJECTIVES: The present study proposes examine frequency, amount, and trends post-operative consumption orthopedic surgical procedures. STUDY D...

Abstract Artificial intelligence (AI) promises major gains in productivity, safety and convenience through automation. Despite the associated euphoria, care needs to be taken ensure that no immature, unsafe products enter market, especially high-risk areas. systems are therefore integrated into European Union’s existing product system by planned AI regulation. This is accomplished horizontally ...

Bipolar is a form of mental disorder that refers to mood disorders include emotional make person not perform their life functions properly where the sufferer will experience sadness from phase depression euphoria and unrealistic in mania phase. The goal study was outline how cognitive behavior therapy (CBT) approaches play role bipolar as well counseling techniques through approaches. Research ...

Mental illness can cause problems in everyday life, not only damage interactions or relationships with other people, but also reduce performance school and work productivity. Mood disorders include a variety of emotional disturbances that make person unable to function, from the sadness depression unrealistic euphoria irritability mania. are most commonly diagnosed mental individuals attempted ...