Hyaluronan-cisplatin conjugate nanoparticles (HCNPs) were chosen as colon-targeting drug-delivery carriers due to the observation that a variety of malignant tumors overexpress hyaluronan receptors. HCNPs were prepared by mixing cisplatin with a hyaluronan solution, followed by dialysis to remove trace elements. The cells treated with HCNPs showed significantly lower viability than those treate...

using ion-exchange resins, a multiple-unit type of oral floating dosage system has been prepared to prolong gastric emptying time of dosage form. the system is composed of beads of drug-resin complex, which are loaded with bicarbonate ions and coated with a hydrophobic polymer. the system is so designed that when the beads reach the stomach, chloride ions are exchanged with bicarbonate and drug...

Article history: Received on: 13/08/2014 Revised on: 09/09/2014 Accepted on: 15/10/2014 Available online: 27/11/2014 Desloratadine (DS) is a tricyclic antihistaminic, characterized by bitter taste and slight water solubility. The aim of this study is to prepare DS as orally disintegrating tablets (ODT) to mask the bitter taste and improve compliance. Twelve different placebo ODT (F1-F12) were p...

The present investigation was aimed to formulate and evaluate the gastro-retentive floating microballoons of glipizide using hydrophilic polymers hydroxypropyl methylcellulose (HPMC) and Eudragit RS100 (RS 100) by emulsion solvent evaporation technique. The floating microballoons were evaluated using micromeritic properties, buoyancy, in vitro drug release, scanning electron microscopy and stab...

The aim of this study was to prepare Eudragit Retard L (Eudragit RL) nanoparticles (ENPs) and to determine their properties, their uptake by the human THP-1 cell line in vitro and their effect on the hematological parameters and erythrocyte damage in rats. ENPs showed an average size of 329.0 ± 18.5 nm, a positive zeta potential value of +57.5 ± 5.47 mV and nearly spherical shape with a smooth ...

We investigate solidification in tantalum and uranium systems ranging in size from 64,000 to 524,288,000 atoms on the IBM BlueGene/L computer at LLNL. Using the newly developed ddcMD code, we achieve performance rates as high as 103 TFlops, with a performance of 101.7 TFlop sustained over a 7 hour run on 131,072 cpus. We demonstrate superb strong and weak scaling. Our calculations are significa...

INTRODUCTION The purpose of this investigation was to evaluate microencapsulated controlled release preparation of theophylline using Eudragit RS 100 as the retardant material with high entrapment efficiency. METHODS Microspheres were prepared by the emulsion-solvent evaporation method. A mixed solvent system consisting of methanol and acetone and light liquid paraffin as oily phase were chos...

Objective: The present study’s objective was to apply a central composite design develop the simvastatin-loaded nanosponge formulation improve its oral bioavailability. Methods: With help of expert (State-Ease version 13.0.1), selected for nanosponges by using defined concentration Eudragit L-100 (X1) and PVA (X2) as independent variables particle size (Y1), percent (%) entrapment efficiency (E...

The purpose of this research was to prepare and evaluate a non-bitter donepezil hydrochloride (DH) orally disintegrating tablet (ODT) for enhanced patient compliance. Taste masking was done by preparing microspheres with different ratios of drug and Eudragit EPO using spray drying method. The entrapment of the drug into microspheres was confirmed by scanning electron microscope (SEM) and X-ray ...

Using ion-exchange resins, a multiple-unit type of oral floating dosage system has been prepared to prolong gastric emptying time of dosage form. The system is composed of beads of drug-resin complex, which are loaded with bicarbonate ions and coated with a hydrophobic polymer. The system is so designed that when the beads reach the stomach, chloride ions are exchanged with bicarbonate and drug...