Eudragit® polymers have proven their potential as a means to control the release of aqueous insoluble drugs in various delivery systems polymer nanoparticles (PNPs). The size (S) and polydispersity index (PDI) PNPs are crucial factors for interaction with biological from pharmaceutical standpoint. This study aimed determine impact volumes organic phase (OP) (AP), well amount (PA), on PDI prepar...

Solid dispersion-based nanofiber formulations of poorly soluble drugs prepared by electrospinning (ES) with a water-soluble polymer, can offer significant improvements in drug dissolution for oral administration. However, when hygroscopic polymers, such as polyvinylpyrrolidone (PVP) are used, environmental moisture sorption lead to poor physical stability on storage. This study investigated the...

The purpose of this study was to synthesize duloxetine (DLX)- loaded Eudragit-Chitosan (Eud-CHT) nanoparticles enclosed in an oral gelatin capsule and evaluate the potential transport DLX blood-brain barrier (BBB)for improved neuro-availability. utilization Eudragit® with chitosan offers a pH-dependent controlled drug release. physicochemical properties formulated DLX-loaded Eud-CHT nanosystem ...

Eudragit RL (ERL) and Eudragit RS (ERS) are biocompatible cationic copolymers, pH-independent and insoluble in aqueous environment. In this study drug delivery system consisting of a capsule filled with floating pellets with verapamil hydrochloride (VH) is proposed. The release of VH in the stomach results in better solubility in an acid gastric environment in vivo and may result in greater amo...

The purpose of this research work was to obtain directly compressible enteric recrystallized agglomerates of erythromycin containing enteric polymers by emulsion solvent diffusion technique. Selected solvent for the process includes the best solvent (ethyl alcohol), non-solvent (distilled water) and bridging liquid (chloroform) according to their solubility in different organic solvent. The dif...

The main objective of this study was to prepare colon-specific pellets of budesonide, using pectin as film coating. Pellet cores of budesonide were prepared by extrusion / spheronization technique. Pectin, in different ratios was combined with Eudragit RS30D, Eudragit NE30D or Surelease to produce film coating. The dissolution profiles of pectin coated pellets were investigated in pH of 1.2 (2 ...

The aim of the present study was to develop a single unit, site-specific matrix tablets of aceclofenac allowing targeted drug release in the colon with a microbially degradable polymeric carrier, chondroitin suphate (CS) and to coat the optimized batches with a pH dependent polymeric. The tablets were prepared by wet granulation method using starch mucilage as a binding agent and HPMC K-100 as ...

The objective of the present study was the development and the in vitro evaluation of extended release multiparticulate dosage forms with carbamazepine, starting from drug crystals of established granulometry as cores and using Eudragit NE aqueous dispersions as coating film polymer in a bottom spray fluid bed coating system. The chosen independent variables, i.e., the quantity of film coating ...