With an increase in the global pollution, there is requirement for an alternative to the fossil fuels. Non-edible vegetable oils are highly promising for producing liquid fuels like diesel. Jatropha is a potential feedstock for biodiesel, currently utilized in India and many parts of the world. The optimization of reaction conditions such as temperature, time, catalyst and molar ratio for biodi...

A facile one step synthesis of anilino alky1-N-substituted phthalimide I is reported. The following compounds belonging to this series were made: 1. (anilino-N-ethyl) phthalimide 8 2. (3,4, 5-trimethoxy anilino-N-ethyl) phthalimide 6 3. (3,4, 5-trimethoxy anilino-N-propyl) phthalimide 7 4. N-(ethyl phthalirnido-p-amino benzoyl) glutamic acid diethyl ester 10 5. N-(propyl phthalimido-p-ami...

Efforts to improve cancer care in the developing world will benefit from the identification of simple, inexpensive, and broadly applicable medical modalities based on emergent innovations in treatment, such as targeting mechanisms of tumoral immune tolerance. In this report, we offer preclinical evidence that the low-cost, anti-inflammatory agent ethyl pyruvate elicits a potent immune-based ant...

BACKGROUND Icosapent ethyl is a high-purity form of eicosapentaenoic acid ethyl ester approved to reduce triglyceride levels in adults with triglycerides ≥500 mg/dL. Candidates for triglyceride-lowering therapy include patients with diabetes mellitus who may be receiving rosiglitazone. We assessed the effects of icosapent ethyl on the pharmacokinetic parameters of rosiglitazone. METHODS Subje...

Mechanisms responsible for alcohol-induced heart muscle disease have been difficult to elucidate partly because of previously obscure, demonstrable cardiac metabolism of ethanol. Recently, fatty acid ethyl esters were identified in our laboratory and found to be myocardial metabolites of ethanol. In the present study, they have been shown to induce mitochondrial dysfunction. Incubation of isola...

PURPOSE Ethyl pyruvate has anti-inflammatory properties and protects organs from ischemia/reperfusion (I/R)-induced tissue injury. The aim of this study was to determine whether ethyl pyruvate decreases the inflammatory response after regional I/R injury and whether ethyl pyruvate protects against delayed regional I/R injury in an in vivo rat heart model after a 24 hours reperfusion. MATERIAL...

BACKGROUND AND OBJECTIVE Icosapent ethyl is a high-purity prescription form of eicosapentaenoic acid ethyl ester approved as an adjunct to diet to reduce triglyceride levels in adult patients with triglyceride levels ≥500 mg/dL (≥5.65 mmol/L). The objective of this open-label, drug-drug interaction study was to examine the effects of icosapent ethyl on the steady-state pharmacokinetics of atorv...

There is a discrepancy between in vitro cholesterol dissolving efficacy of methyl-tert-butyl ether (MTBE) and ethyl propionate and cholesterol gall stone dissolution in vivo. This study investigated whether the presence of bile changes the cholesterol dissolving capacity of MTBE and ethyl propionate. The addition of dimethylsulphoxide to MTBE or ethyl propionate was also studied to discover if ...

Biodiesel, defined as mono-alkyl esters of long-chain fatty acids derived from vegetable oils or animal fats, is an attractive renewable fuel alternative to conventional petroleum diesel fuel. Biodiesel produced from oils such as cottonseed oil and poultry fats suffer from extremely poor cold flow properties because of their high saturated fatty acid content. In the current study, Ethyl Levulin...

The fruity odours of wine are largely derived from the synthesis of esters and higher alcohols during yeast fermentation. The ATF1- and ATF2-encoded alcohol acetyltransferases of S. cerevisiae are responsible for the synthesis of ethyl acetate and isoamyl acetate esters, while the EHT1-encoded ethanol hexanoyl transferase is responsible for synthesizing ethyl caproate. However, esters such as t...