Previous studies have shown variability in naphthalene cytotoxicity, expression of CYP2F2 gene and protein, and naphthalene metabolism in random cycling female mice (NIH:Swiss). CYP2F2 metabolizes naphthalene to cytotoxic metabolites in lungs of mice. This study was designed to address the question: do hormonal changes associated with the estrous cycle alter metabolism of naphthalene in the lun...

The present study determined vascular changes in the bovine corpus luteum (CL) at Day 16 (early maternal recognition period) and Day 40 in early pregnancy and compared them to the CL from Day 12 and Day 16 of the estrous cycle. The CLs were analyzed in the central and peripheral regions, where site-depending features of vessels and angiogenic factors are evident. The same protein level of the e...

Felids generally follow a poly-estrous reproductive strategy. Eurasian lynx (Lynx lynx) display a different pattern of reproductive cyclicity where physiologically persistent corpora lutea (CLs) induce a mono-estrous condition which results in highly seasonal reproduction. The present study was based around a sono-morphological and endocrine study of captive Eurasian lynx, and a control-study o...

Estrus has been synchronized in cattle with progestogens, prostaglandins (prostaglandin F2 alpha and its analogues), progestogen-estrogen combinations and progestogen-prostaglandin combinations. Progestogens administered for 14 to 20 d are effective in synchronizing estrus; however, fertility at the synchronized estrus is subnormal. Duration of progestogen treatment can be reduced by combining ...

Bradshaw, Heather B., Neta Rimmerman, Jocelyn F. Krey, and J. Michael Walker. Sex and hormonal cycle differences in rat brain levels of pain-related cannabimimetic lipid mediators. Am J Physiol Regul Integr Comp Physiol 291: R349–R358, 2006. First published March 23, 2006; doi:10.1152/ajpregu.00933.2005.—One important function of endocannabinoids and related lipid mediators in mammalian central...

In the present study, we investigated the effect of PPAR ligands on progesterone (P4) and 17β-estradiol (E2) secretion, as well as 3β-hydroxysteroid dehydrogenase/Δ(5)-Δ(4) isomerase (3β-HSD) mRNA expression, in porcine endometrial slices collected on days 10–12 and 14–16 of the estrous cycle or early pregnancy. The explants were incubated in vitro for 6 h in the presence of PPARα ligands – WY-...

Two experiments were conducted to determine whether extending the interval between removal of melengestrol acetate (MGA) from feed and injection of prostaglandin F2α (PGF) from 17 to 19 d would affect synchronization of estrus, conception, and pregnancy rates of beef heifers. In both experiments, heifers were fed MGA for 14 d, and PGF was given at either 17 or 19 d after cessation of MGA feedin...

For 6 years adult, non-synchronized Hampshire ewes (n=2,5,8,8,9 and 12) and rams (n=6,10,12,11,11 and 9) were maintained separately and released to contiguous pastures having in common a woven-wire fence about 80m long and 1.1m high. Natural estrous cycles were monitored daily by observations of ram-seeking behavior as defined as a ewe being persistent in staying at the common fence with attent...

Ghrelin, a novel motilin-related endogenous ligand for growth hormone secretagouge receptor, is implicated in various biological functions, including regulation of female reproduction. But the presence of ghrelin and its role in reproductive functions in buffalo, a species with poor reproductive efficiency, is not known. In the present study full-length ghrelin cDNA was isolated from bubaline a...

The ferret is a reflex-ovulating species in which receipt of an intromission induces a prolonged (612 h) preovulatory LH surge in the estrous female. This LH surge is probably stimulated by a large release of GnRH from the mediobasal hypothalamus (MBH). In Exp 1 we asked whether GnRH messenger RNA (mRNA) levels increase in response to mating so as to replenish the MBH GnRH stores needed to sust...