Mixed adenoneuroendocrine carcinomas (MANEC) are characterized by the simultaneous presence of an exocrine glandular component and a neuroendocrine component. They are rare, heterogeneous tumors that present a very variable morphological/clinical profile and prognosis. We present the case of a 69-year-old man with controlled hypertension, who reported progressive dysphagia over the previous 4 m...

Left portal hypertension and splenic vein occlusion commonly occur with pancreatic tumors, however these signs are rarely observed in patients with acinar cell carcinoma. This report describes a rare left portal hypertension in a patient who presented with a dilated esophagogastric vein upon esophagogastroduodenoscopic examination of a gastric polyp. A contrast-enhanced computed tomography scan...

Acanthosis nigricans (AN) is a hyperpigmented keratotic skin lesion known to be associated with malignant disease and endocrinopathy. We report a very rare case of generalized AN with Sjögren's syndrome- and systemic lupus erythematosus-like features but without type B insulin resistance. Neither internal malignancy nor other endocrinological disorders, including glucose intolerance, were detec...

The incidence of esophagogastric cancers is increasing rapidly in the Western population. Despite better understanding of the biology and intense research in the treatment of these cancers, the long-term survival remains poor both in the locally advanced and metastatic settings. The addition of combined modality strategies has resulted in modest improvement in 5-year survival rates. A number of...

 Abstract Background: End-to-side esophagojejunostomy has almost always been associated with some degree of dysphagia. To overcome this complication we decided to perform an end-to-end anastomosis and compare it with end-to-side Roux-en-Y esophagojejunostomy. Methods: In this prospective study, between 1998 and 2005, 71 patients with a diagnosis of gastric adenocarcinoma underwent total gastrec...

30 ‘circular’ vs. oblique ‘elliptical’ anastomosis extended on the left PA, evaluating pressure and velocity profiles, and shear stress, from PA 31 origin to the bifurcation. ‘Elliptical’ anastomosis provides larger (s54% difference) cross-sectional area than ‘circular’ anastomosis. Velocity 32 contours showed important stagnation at PA bifurcation in ‘circular’ anastomosis and minimal in ‘elli...

A computational fluid dynamic (CFD) study compared two configurations of distal anastomosis of 12 mm Contegra conduit: conventional 'circular' vs. oblique 'elliptical' anastomosis extended on the left PA, evaluating pressure and velocity profiles, and shear stress, from PA origin to the bifurcation. 'Elliptical' anastomosis provides larger (=54% difference) cross-sectional area than 'circular' ...