HYPOTHESIS Preoperative assessment can identify the predictors of esophageal shortening in patients with gastroesophageal reflux disease. DESIGN AND SETTING Patient comparison study in a university-based tertiary care center. PATIENTS A total of 236 patients with gastroesophageal reflux disease underwent primary antireflux procedures. Sixty-five patients were suspected of having a short eso...

HYPOTHESIS Helicobacter pylori is not associated with gastroesophageal reflux disease and its complications, including adenocarcinoma of the esophagus and the gastroesophageal junction (GEJ). DESIGN Retrospective analysis. SETTING University tertiary referral center. PATIENTS Two hundred twenty-nine patients with symptoms suggestive of foregut disease underwent esophageal manometry, 24-ho...

BACKGROUND Globus pharyngeus is common and has a low cure rate. Its etiology is complex and reported to be associated with laryngopharyngeal reflux (LPR). However, some patients with globus do not exhibit any reflux symptoms or respond to proton pump inhibitors (PPIs) treatments. The purpose of this study was to clarify the related risk factors of these patients with a final objective of improv...

BACKGROUND Asthma, laryngitis and chronic cough are atypical symptoms of the gastroesophageal reflux disease. AIM To analyze the efficacy of laparoscopic surgery in the remission of extra-esophageal symptoms in patients with gastroesophageal reflux, related to asthma. METHODS Were reviewed the medical records of 400 patients with gastroesophageal reflux disease submitted to laparoscopic Nis...

Background/Aims Gastroesophageal reflux disease (GERD) is the most common cause of non-cardiac chest pain (NCCP). Currently available data reveal a weak relationship between NCCP and dysmotility. Moreover, it is unclear why some refluxes are perceived as heartburn and others as NCCP. We aimed to evaluate the role of the reflux pattern and the esophageal motility in patients with NCCP. Methods...

Cardiac and esophageal causes of atypical pain in the chest are often a difficult diagnostic problem. The pain is considered atypical because of its unusual distribution or unusual precipitating and relieving factors. One hundred and five patients with such pain were evaluated by complete esophageal and cardiac investigation. Based on the results of the investigations, 43 patients were found to...

Submit Manuscript | http://medcraveonline.com The incidence of reflux disease or Gastro-Esophageal or Gastro-Laryngeal reflux reaches up to over 50% of the general population and natural history includes periods of wellness, alternating with periods of exacerbation. The flat mucosa of esophagus is not designed to withstand the irritating contents, which come from the stomach, and this creates p...

BACKGROUND/AIMS Prokinetic drugs such as metoclopramide are frequently used as second-line therapy for patients with gastroesophageal reflux disease. However, their beneficial effects remain unclear. Esophageal motor activities and compliance of the esophagogastric junction (EGJ) are important for prevention of gastroesophageal reflux. Although metoclopramide has been reported to increase lower...

CONTEXT Gastroesophageal reflux disease is one of the most common digestive diseases and an important cause of distress to patients. Diagnosis of this condition can require ambulatory pH monitoring. OBJECTIVES To determine the diagnostic yield of a wireless ambulatory pH monitoring system of 48-hours, recording to diagnose daily variability of abnormal esophageal acid exposure and its symptom...

The literature review focuses on the current understanding of visceral hypersensitivity mechanisms in esophagus. Mechanisms peripheral and central sensitization their relation to heartburn symptoms are covered detail. Diagnostic criteria algorithms for non-erosive reflux disease, functional heartburn, esophagus based pH-impedance testing high-resolution esophageal manometry data presented.