While studying the functions of CCM3/PDCD10, a gene encoding an adaptor protein whose mutation results in vascular malformations, we have found that it is involved in a novel response to oxidative stress that results in phosphorylation and activation of the ezrin/radixin/moesin (ERM) family of proteins. This phosphorylation protects cells from accidental cell death induced by oxidative stress. ...

in epithelial integrity, polarity, and junction formation was suggested for the Drosophila ERM ortholog Dmoesin, which was proposed to act by antagonizing rho signaling rather than by providing a structural function (Polesello et al., 2002; Speck et al., 2003). A role of ERM Verena Göbel,1,* Peter L. Barrett,1 David H. Hall,2 and John T. Fleming1 Laboratory of Developmental Immunology Massachus...

OBJECTIVE This study was to aggregate the prevalence and risks of epiretinal membranes (ERMs) and determine the possible causes of the varied estimates. DESIGN Systematic review and meta-analysis. DATA SOURCES The search strategy was designed prospectively. We searched PubMed, Embase and Web of Science databases from inception to July 2016. Reference lists of the included literatures were r...

The major goal of periodontal therapy is periodontal regeneration including regeneration of alveolar bone, cementum and periodontal ligament fibres. Recapitulation of embryology shows the importance of Hertwig's epithelial root sheath (HERS), involved in cementogenesis and root formation. The remnants of these cells are found in normal periodontal ligament as the epithelial cell rests of Malass...

ERM (Ezrin, Radixin, Moesin) proteins are membrane-cytoskeleton linkers that regulate the structure and the function of specific domains of the plasma membrane. ERM proteins are expressed in all metazoan analyzed so far. Genetic analysis of ERM protein functions has recently been performed simultaneously in three different organisms, mouse, Drosophila melanogaster and C. elegans. These studies ...

We have previously demonstrated that the CCR9/CCL25 signaling pathway plays an important role in drug resistance in human acute T-lymphocytic leukemia (T-ALL) by inducing activation of ERM protein with polarized distribution in T-ALL cell line MOLT4. However, the mechanism of action of the activated ERM protein in the drug resistance of MOLT4 cells induced by CCL25 remains uncharacterized. Here...

The COVID-19 pandemic has had a devastating impact on many small and medium-sized businesses around the world. Enterprise risk management (ERM) is conceptual framework that encompasses systematic comprehensive identification, analysis, of risks in an enterprise. In post-communist countries Central Europe, level ERM still relatively low, especially enterprises (SMEs). This study fills gap existi...

We characterize the mechanisms implicated in an unusual phenotype of resistance to macrolides-lincosamides (no halos of inhibition around clindamycin and lincomycin discs, and a 15 mm halo around erythromycin disc) in a Streptococcus agalactiae isolate recovered in Spain. The presence of macrolide or lincosamide resistance genes [erm(A), erm(B), erm(C), erm(T), mef(A), mrs(A), lnu(A), lnu(B), l...