BACKGROUND Endocrine-disrupting chemicals (EDCs) are widely found in the environment. Estrogen-like activity is attributed to EDCs, such as bisphenol A (BPA), bisphenol AF (BPAF), and zearalenone (Zea), but mechanisms of action and diversity of effects are poorly understood. OBJECTIVES We used in vitro models to evaluate the mechanistic actions of BPA, BPAF, and Zea on estrogen receptor (ER) ...

Background: Estrogen stimulates the proliferation of cells in normal mammary glands and most estrogen receptor (ER)positive mammary carcinomas by binding to the ER and promoting the transcription of ER-responsive genes. In cells with functional ERs, estrogen mediates the transition of cells from the G1 to S phase of the cell cycle. Several cell cycle regulatory proteins have been implicated in ...

Forkhead box protein A1 (FOXA1) is essential for the growth and differentiation of breast epithelium, and has a favorable outcome in breast cancer (BC). Elevated FOXA1 expression in BC also facilitates hormone responsiveness in estrogen receptor (ESR)-positive BC. However, the interaction between these two pathways is not fully understood. FOXA1 and GATA binding protein 3 (GATA3) along with ESR...

[Abstract] A theoretical analysis of electronic-resonance-enhanced (ERE) coherent anti-Stokes Raman scattering (CARS) of NO is discussed. The time-dependent density matrix equations for the nonlinear ERE-CARS process are derived and manipulated into a form suitable for direct numerical integration (DNI). In the ERE-CARS configuration considered in this paper, the pump and Stokes beams are far f...

Neuronal expression of vasopressin messenger RNA (mRNA) and peptide has been shown to be estrogen dependent. A 5.5-kb genomic DNA fragment, 59 of the AVP coding region, was used in luciferase reporter assays to measure transcriptional activation by either estrogen receptor a or b in response to various treatments. ERa and ERb displayed differential regulation of the AVP promoter. SK-N-SH cells ...

No início de 2020 o mundo foi surpreendido pelo surgimento e rápido avanço da Covid-19. O impacto sobre os programas educacionais enorme. Sendo distanciamento social uma das poucas formas mitigar pandemia, ensino remoto emergencial (ERE) passou a ser imposição. Neste contexto ganha grande relevância avaliar estas iniciativas fim promover rapidamente as mudanças necessárias para que se consiga, ...

About 20 of the 250 M ichigan gam e tickets availab le to s tu ­ dents w ere reserv ed for use by m em bers of the S tudent Union B oard before a lo ttery w as held to d istribu te the tickets, B oard d irec to r Jan e l B lount said W ed­ nesday night. At least six tickets w ent to friends and room m ates of B oard m em bers, said SUB S er­ vices C om m issioner J im H ering, who ran the lo tt...

In this work, we first present an application-initiated strategy that aims to control the energy consumption, while simultaneously enhancing the performance of a heterogeneous embedded system. We assess the benefits of using this strategy by means of a traditional evaluation framework. Even though the overall benefits and improvements are apparent, the performance-energy tradeoffs are not promi...

Distributed constraint satisfaction problems (DisCSPs) are among the widely endeavored problems using agent-based simulation. Fernandez et al. formulated sensor and mobile tracking problem as a DisCSP, known as SensorDCSP In this paper, we adopt a customized ERE (environment, reactive rules and entities) algorithm for the SensorDCSP, which is otherwise proven as a computationally intractable pr...