Objectives-To investigate whether sputum cytology can be used to monitor epithelial cell changes in groups at high risk of lung cancer from exposure to radiation. Methods-Dysplasia of bronchial cells was investigated by means of sputum cytology in a group of 434 underground miners. 100 of them were not exposed, and 334 were exposed to 222Rn progeny at cumulative exposures < 450 working level mo...

From the ABCC-RERF Life Span Study extended sample, there were 4,499 cases in the Pathology Study sample of atomic bomb survivors who had come to autopsy in the period 1960-83. Among 370 subjects who were heavily exposed with an estimated dose (T65D) of 100 rad or more, 72 (about 20%) of them, whose urinary bladder epithelia had been preserved satisfactorily to suit the purpose of this study, w...

Multiphoton fluorescence lifetime imaging microscopy (FLIM) is a noninvasive, cellular resolution, 3-D functional imaging technique. We investigate the potential for in vivo precancer diagnosis with metabolic imaging via multiphoton FLIM of the endogenous metabolic cofactor nicotinamide adenine dinucleotide (NADH). The dimethylbenz[alpha]anthracene (DMBA)-treated hamster cheek pouch model of or...

Objective. To perform a systematic review and meta-analysis on studies that assess malignant transformation rates (MTR) of oral epithelial dysplasia. Materials and Methods. This review was planned and conducted in accordance with the meta-analysis of observational studies in epidemiology (MOOSE) guidelines. PubMed, EMBASE, Google Scholar, and Cochrane databases were screened to identify observa...

Oral lichen planus (OLP) is classified as a potentially malignant disorder. Systematic reviews collating longitudinal observation studies provide evidence of the rate or proportion transformation. We conducted an umbrella study published systematic reviews. An extensive English-language search was carried out in several databases to identify relevant articles, providing on transformation OLP. D...

TP63 gene encodes p63, which is a major transcription factor of the epithelial system. Mutations in underlie variety autosomal dominantly-inherited ectodermal dysplasia syndromes, which, most cases, share several symptoms including cleft lip/palate. In this study, we analyzed child with certain showing hypotrichosis, oligodontia, and hypoplastic nails, but did not have We identified novel heter...

This case report describes a patient with chronic ulcerative colitis and epithelial dysplasia of 17 y duration ultimately complicated by colonic carcinoma. At laparotomy, clinically unsuspected but typical Crohn's disease of the terminal ileum was also found. The macroscopic and histological features of the resected terminal ileum were characteristic of Crohn's disease.